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Increased Incidence of Type 1 Diabetes in Children and No Change in the Age of Diagnosis and BMI-SDS at the Onset - is the Accelerator Hypothesis not Working?

OBJECTIVE: One of the hypothesized reasons for the observed increase in type 1 diabetes incidence in children is weight gain, causing accelerated disease development in predisposed individuals. This so-called accelerator hypothesis is, however, controversial. The aim was to analyze whether, in the e...

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Autores principales: Wasyl-Nawrot, Barbara, Wójcik, Małgorzata, Nazim, Joanna, Skupień, Jan, Starzyk, Jerzy B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499142/
https://www.ncbi.nlm.nih.gov/pubmed/31990164
http://dx.doi.org/10.4274/jcrpe.galenos.2020.2019.0133
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author Wasyl-Nawrot, Barbara
Wójcik, Małgorzata
Nazim, Joanna
Skupień, Jan
Starzyk, Jerzy B.
author_facet Wasyl-Nawrot, Barbara
Wójcik, Małgorzata
Nazim, Joanna
Skupień, Jan
Starzyk, Jerzy B.
author_sort Wasyl-Nawrot, Barbara
collection PubMed
description OBJECTIVE: One of the hypothesized reasons for the observed increase in type 1 diabetes incidence in children is weight gain, causing accelerated disease development in predisposed individuals. This so-called accelerator hypothesis is, however, controversial. The aim was to analyze whether, in the ethnically homogeneous population of Lesser Poland, an increase in the number of cases of diabetes among children was associated with younger age and higher body mass index-standard deviation score (BMI-SDS) at the time of diagnosis. METHODS: Retrospective data analysis from medical records of all patients <14 years (n=559; 50.6% male), with newly diagnosed type 1 diabetes, in Lesser Poland between 1(st) January 2006 and 31(st) December 2017 (11 years). RESULTS: The incidence ratio ranged significantly (p<0.001) from the lowest in 2006 (11.2/100,000/year) to the highest in 2012 (21.9/100,000/year). The mean age of diagnosis was 8.2±3.5 years. There was no trend in decreasing diagnosis age (p=0.43). The mean BMI-SDS was -0.4±1.2. Almost all children (91.6%) presented with BMI-SDS within the normal range at the time of diagnosis, with only 2.7% of cases being obese and 5.7% underweight at the moment of diagnosis. There was no clear trend at all in BMI-SDS over the study period. CONCLUSION: These results do not corroborate an increase of type 1 incidence in paediatric population being associated with younger age of diagnosis and higher BMI-SDS. This implies that the accelerator hypothesis does not hold true in the study population.
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spelling pubmed-74991422020-09-23 Increased Incidence of Type 1 Diabetes in Children and No Change in the Age of Diagnosis and BMI-SDS at the Onset - is the Accelerator Hypothesis not Working? Wasyl-Nawrot, Barbara Wójcik, Małgorzata Nazim, Joanna Skupień, Jan Starzyk, Jerzy B. J Clin Res Pediatr Endocrinol Original Article OBJECTIVE: One of the hypothesized reasons for the observed increase in type 1 diabetes incidence in children is weight gain, causing accelerated disease development in predisposed individuals. This so-called accelerator hypothesis is, however, controversial. The aim was to analyze whether, in the ethnically homogeneous population of Lesser Poland, an increase in the number of cases of diabetes among children was associated with younger age and higher body mass index-standard deviation score (BMI-SDS) at the time of diagnosis. METHODS: Retrospective data analysis from medical records of all patients <14 years (n=559; 50.6% male), with newly diagnosed type 1 diabetes, in Lesser Poland between 1(st) January 2006 and 31(st) December 2017 (11 years). RESULTS: The incidence ratio ranged significantly (p<0.001) from the lowest in 2006 (11.2/100,000/year) to the highest in 2012 (21.9/100,000/year). The mean age of diagnosis was 8.2±3.5 years. There was no trend in decreasing diagnosis age (p=0.43). The mean BMI-SDS was -0.4±1.2. Almost all children (91.6%) presented with BMI-SDS within the normal range at the time of diagnosis, with only 2.7% of cases being obese and 5.7% underweight at the moment of diagnosis. There was no clear trend at all in BMI-SDS over the study period. CONCLUSION: These results do not corroborate an increase of type 1 incidence in paediatric population being associated with younger age of diagnosis and higher BMI-SDS. This implies that the accelerator hypothesis does not hold true in the study population. Galenos Publishing 2020-09 2020-09-02 /pmc/articles/PMC7499142/ /pubmed/31990164 http://dx.doi.org/10.4274/jcrpe.galenos.2020.2019.0133 Text en ©Copyright 2020 by Turkish Pediatric Endocrinology and Diabetes Society | The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Wasyl-Nawrot, Barbara
Wójcik, Małgorzata
Nazim, Joanna
Skupień, Jan
Starzyk, Jerzy B.
Increased Incidence of Type 1 Diabetes in Children and No Change in the Age of Diagnosis and BMI-SDS at the Onset - is the Accelerator Hypothesis not Working?
title Increased Incidence of Type 1 Diabetes in Children and No Change in the Age of Diagnosis and BMI-SDS at the Onset - is the Accelerator Hypothesis not Working?
title_full Increased Incidence of Type 1 Diabetes in Children and No Change in the Age of Diagnosis and BMI-SDS at the Onset - is the Accelerator Hypothesis not Working?
title_fullStr Increased Incidence of Type 1 Diabetes in Children and No Change in the Age of Diagnosis and BMI-SDS at the Onset - is the Accelerator Hypothesis not Working?
title_full_unstemmed Increased Incidence of Type 1 Diabetes in Children and No Change in the Age of Diagnosis and BMI-SDS at the Onset - is the Accelerator Hypothesis not Working?
title_short Increased Incidence of Type 1 Diabetes in Children and No Change in the Age of Diagnosis and BMI-SDS at the Onset - is the Accelerator Hypothesis not Working?
title_sort increased incidence of type 1 diabetes in children and no change in the age of diagnosis and bmi-sds at the onset - is the accelerator hypothesis not working?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499142/
https://www.ncbi.nlm.nih.gov/pubmed/31990164
http://dx.doi.org/10.4274/jcrpe.galenos.2020.2019.0133
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