mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

Cancer cells have a characteristic metabolism, mostly caused by alterations in signal transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to be cancer-selective, signaling alterations need to be identified that confer a druggable vulnerability. Here, we demonstrate...

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Detalles Bibliográficos
Autores principales: Gremke, Niklas, Polo, Pierfrancesco, Dort, Aaron, Schneikert, Jean, Elmshäuser, Sabrina, Brehm, Corinna, Klingmüller, Ursula, Schmitt, Anna, Reinhardt, Hans Christian, Timofeev, Oleg, Wanzel, Michael, Stiewe, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499183/
https://www.ncbi.nlm.nih.gov/pubmed/32943635
http://dx.doi.org/10.1038/s41467-020-18504-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499183/
https://www.ncbi.nlm.nih.gov/pubmed/32943635
http://dx.doi.org/10.1038/s41467-020-18504-7

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