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mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability
Cancer cells have a characteristic metabolism, mostly caused by alterations in signal transduction networks rather than mutations in metabolic enzymes. For metabolic drugs to be cancer-selective, signaling alterations need to be identified that confer a druggable vulnerability. Here, we demonstrate...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499183/ https://www.ncbi.nlm.nih.gov/pubmed/32943635 http://dx.doi.org/10.1038/s41467-020-18504-7 |