Importance of Stability Analysis When Using Nonlinear Semimechanistic Models to Describe Drug‐Induced Hematotoxicity

Stability analysis, often overlooked in pharmacometrics, is essential to explore dynamical systems. The model developed by Friberg et al.(1) to describe drug‐induced hematotoxicity is widely used to support decisions across drug development, and parameter values are often identified from observed bl...

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Detalles Bibliográficos
Autores principales: Fornari, Chiara, Pin, Carmen, Yates, James W.T., Mettetal, Jerome T., Collins, Teresa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499189/
https://www.ncbi.nlm.nih.gov/pubmed/32453487
http://dx.doi.org/10.1002/psp4.12514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499189/
https://www.ncbi.nlm.nih.gov/pubmed/32453487
http://dx.doi.org/10.1002/psp4.12514

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