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Tumor cells rely on the thiol oxidoreductase PDI for PERK signaling in order to survive ER stress
Upon ER stress cells activate the unfolded protein response through PERK, IRE1 and ATF6. Remarkable effort has been made to delineate the downstream signaling of these three ER stress sensors after activation, but upstream regulation at the ER luminal site still remains mostly undefined. Here we rep...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499200/ https://www.ncbi.nlm.nih.gov/pubmed/32943707 http://dx.doi.org/10.1038/s41598-020-72259-1 |