Dual inhibition of HDAC and tyrosine kinase signaling pathways with CUDC-907 attenuates TGFβ1 induced lung and tumor fibrosis

TGFβ1 signaling is a critical driver of collagen accumulation in pulmonary fibrotic diseases and a well-characterized regulator of cancer associated fibroblasts (CAF) activation in lung cancer. Myofibroblasts induced by TGFβ1 and other factors are key players in the pathogenesis of lung fibrosis and...

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Detalles Bibliográficos
Autores principales: Zhang, Wentian, Zhang, Yajie, Tu, Tian, Schmull, Sabastian, Han, Yu, Wang, Wenbo, Li, Hecheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499263/
https://www.ncbi.nlm.nih.gov/pubmed/32943605
http://dx.doi.org/10.1038/s41419-020-02916-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499263/
https://www.ncbi.nlm.nih.gov/pubmed/32943605
http://dx.doi.org/10.1038/s41419-020-02916-w

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