A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or v...

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Autores principales: Huang, Angkana T., Garcia-Carreras, Bernardo, Hitchings, Matt D. T., Yang, Bingyi, Katzelnick, Leah C., Rattigan, Susan M., Borgert, Brooke A., Moreno, Carlos A., Solomon, Benjamin D., Trimmer-Smith, Luke, Etienne, Veronique, Rodriguez-Barraquer, Isabel, Lessler, Justin, Salje, Henrik, Burke, Donald S., Wesolowski, Amy, Cummings, Derek A. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499300/
https://www.ncbi.nlm.nih.gov/pubmed/32943637
http://dx.doi.org/10.1038/s41467-020-18450-4
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author Huang, Angkana T.
Garcia-Carreras, Bernardo
Hitchings, Matt D. T.
Yang, Bingyi
Katzelnick, Leah C.
Rattigan, Susan M.
Borgert, Brooke A.
Moreno, Carlos A.
Solomon, Benjamin D.
Trimmer-Smith, Luke
Etienne, Veronique
Rodriguez-Barraquer, Isabel
Lessler, Justin
Salje, Henrik
Burke, Donald S.
Wesolowski, Amy
Cummings, Derek A. T.
author_facet Huang, Angkana T.
Garcia-Carreras, Bernardo
Hitchings, Matt D. T.
Yang, Bingyi
Katzelnick, Leah C.
Rattigan, Susan M.
Borgert, Brooke A.
Moreno, Carlos A.
Solomon, Benjamin D.
Trimmer-Smith, Luke
Etienne, Veronique
Rodriguez-Barraquer, Isabel
Lessler, Justin
Salje, Henrik
Burke, Donald S.
Wesolowski, Amy
Cummings, Derek A. T.
author_sort Huang, Angkana T.
collection PubMed
description Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.
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spelling pubmed-74993002020-10-01 A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity Huang, Angkana T. Garcia-Carreras, Bernardo Hitchings, Matt D. T. Yang, Bingyi Katzelnick, Leah C. Rattigan, Susan M. Borgert, Brooke A. Moreno, Carlos A. Solomon, Benjamin D. Trimmer-Smith, Luke Etienne, Veronique Rodriguez-Barraquer, Isabel Lessler, Justin Salje, Henrik Burke, Donald S. Wesolowski, Amy Cummings, Derek A. T. Nat Commun Article Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research. Nature Publishing Group UK 2020-09-17 /pmc/articles/PMC7499300/ /pubmed/32943637 http://dx.doi.org/10.1038/s41467-020-18450-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Huang, Angkana T.
Garcia-Carreras, Bernardo
Hitchings, Matt D. T.
Yang, Bingyi
Katzelnick, Leah C.
Rattigan, Susan M.
Borgert, Brooke A.
Moreno, Carlos A.
Solomon, Benjamin D.
Trimmer-Smith, Luke
Etienne, Veronique
Rodriguez-Barraquer, Isabel
Lessler, Justin
Salje, Henrik
Burke, Donald S.
Wesolowski, Amy
Cummings, Derek A. T.
A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
title A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
title_full A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
title_fullStr A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
title_full_unstemmed A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
title_short A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
title_sort systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499300/
https://www.ncbi.nlm.nih.gov/pubmed/32943637
http://dx.doi.org/10.1038/s41467-020-18450-4
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