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Disulfiram-Induced Acute Liver Injury

Disulfiram is a drug used to treat alcohol dependence since many years. It interferes with the metabolism of alcohol, may be associated with neurological and dermatological symptoms, and can be hepatotoxic. Due to the frequent coexistent liver test alterations due to alcohol, the true incidence of d...

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Autores principales: Ramer, Lucas, Tihy, Matthieu, Goossens, Nicolas, Frossard, Jean-Louis, Rubbia-Brandt, Laura, Spahr, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499310/
https://www.ncbi.nlm.nih.gov/pubmed/32963852
http://dx.doi.org/10.1155/2020/8835647
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author Ramer, Lucas
Tihy, Matthieu
Goossens, Nicolas
Frossard, Jean-Louis
Rubbia-Brandt, Laura
Spahr, Laurent
author_facet Ramer, Lucas
Tihy, Matthieu
Goossens, Nicolas
Frossard, Jean-Louis
Rubbia-Brandt, Laura
Spahr, Laurent
author_sort Ramer, Lucas
collection PubMed
description Disulfiram is a drug used to treat alcohol dependence since many years. It interferes with the metabolism of alcohol, may be associated with neurological and dermatological symptoms, and can be hepatotoxic. Due to the frequent coexistent liver test alterations due to alcohol, the true incidence of disulfiram-associated liver injury is unclear and severity of injury may vary from mildly elevated liver enzymes to fulminant hepatitis leading to death. There are several reported cases of disulfiram hepatitis in the literature. Liver histology, when available, demonstrates some degree of portal inflammation with eosinophils and hepatocyte necrosis. We present here a well-documented case of acute hepatitis due to disulfiram with typical histological lesions, favorable outcome following drug withdrawal, and a brief steroid course. The risk of hepatotoxicity should be kept in mind when prescribing disulfiram.
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spelling pubmed-74993102020-09-21 Disulfiram-Induced Acute Liver Injury Ramer, Lucas Tihy, Matthieu Goossens, Nicolas Frossard, Jean-Louis Rubbia-Brandt, Laura Spahr, Laurent Case Reports Hepatol Case Report Disulfiram is a drug used to treat alcohol dependence since many years. It interferes with the metabolism of alcohol, may be associated with neurological and dermatological symptoms, and can be hepatotoxic. Due to the frequent coexistent liver test alterations due to alcohol, the true incidence of disulfiram-associated liver injury is unclear and severity of injury may vary from mildly elevated liver enzymes to fulminant hepatitis leading to death. There are several reported cases of disulfiram hepatitis in the literature. Liver histology, when available, demonstrates some degree of portal inflammation with eosinophils and hepatocyte necrosis. We present here a well-documented case of acute hepatitis due to disulfiram with typical histological lesions, favorable outcome following drug withdrawal, and a brief steroid course. The risk of hepatotoxicity should be kept in mind when prescribing disulfiram. Hindawi 2020-09-09 /pmc/articles/PMC7499310/ /pubmed/32963852 http://dx.doi.org/10.1155/2020/8835647 Text en Copyright © 2020 Lucas Ramer et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ramer, Lucas
Tihy, Matthieu
Goossens, Nicolas
Frossard, Jean-Louis
Rubbia-Brandt, Laura
Spahr, Laurent
Disulfiram-Induced Acute Liver Injury
title Disulfiram-Induced Acute Liver Injury
title_full Disulfiram-Induced Acute Liver Injury
title_fullStr Disulfiram-Induced Acute Liver Injury
title_full_unstemmed Disulfiram-Induced Acute Liver Injury
title_short Disulfiram-Induced Acute Liver Injury
title_sort disulfiram-induced acute liver injury
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499310/
https://www.ncbi.nlm.nih.gov/pubmed/32963852
http://dx.doi.org/10.1155/2020/8835647
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