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Comparative Evaluation of Colon Cancer Specific Antigen-2 Test and Chromocolonoscopy for Early Detection of Egyptian Patients with Colorectal Cancer

Background: Effective screening of colorectal cancer (CRC) in early stage could reduce the advancement of CRC and therefore mortality. Effective screening is based on either stool dependent tests or colon dependent examination. Aims: The aim of the study was a comparative evaluation of chromocolonos...

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Autores principales: Elhossary, Marwa, Hawash, Nehah, Badawi, Rehab, Yousef, Mohamed, Abd-Elsalam, Sherief, Elhendawy, Mohammed, Wasfy, Rania, Abou-Saif, Sabry, ElBendary, Amal, Ismail, Saber
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499350/
https://www.ncbi.nlm.nih.gov/pubmed/31241019
http://dx.doi.org/10.2174/1871523018666190625164100
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author Elhossary, Marwa
Hawash, Nehah
Badawi, Rehab
Yousef, Mohamed
Abd-Elsalam, Sherief
Elhendawy, Mohammed
Wasfy, Rania
Abou-Saif, Sabry
ElBendary, Amal
Ismail, Saber
author_facet Elhossary, Marwa
Hawash, Nehah
Badawi, Rehab
Yousef, Mohamed
Abd-Elsalam, Sherief
Elhendawy, Mohammed
Wasfy, Rania
Abou-Saif, Sabry
ElBendary, Amal
Ismail, Saber
author_sort Elhossary, Marwa
collection PubMed
description Background: Effective screening of colorectal cancer (CRC) in early stage could reduce the advancement of CRC and therefore mortality. Effective screening is based on either stool dependent tests or colon dependent examination. Aims: The aim of the study was a comparative evaluation of chromocolonoscopy and Colon Cancer-Specific Antigen-2 test for early detection of colorectal cancer in Egyptian patients. Methods: This case control study was carried out on 55 patients classified into 3 groups: Group I consisted of twenty patients with precancerous lesions detected by colonoscopy, Group II consisted of twenty patients diagnosed with colorectal cancer and Group III consisted of fifteen individuals (who underwent colonoscopy for other indications) as a control group. All the subjects were subjected to measure occult blood in the stool, measurement of Colon Cancer-Specific Antigen-2 level in serum and tissue and chromo colonoscopy using Indigo Carmine stain. Results: In group II, there was a statistically significant increase in CCSA2 in serum as compared to the other 2 groups. Cutoff >11.3 CCSA2 in serum showed 65% sensitivity, 85% specificity, 81.2% PPV, 70.8% NPV and 70.3% accuracy in the differentiation of group II with cancer colon from group I with premalignant colonic lesions. A cutoff > 9.1 CCSA2 in serum showed 95% sensitivity, 46.67% specificity, 70.4% PPV, 87.5% NPV and 73.5% accuracy in differentiating group II with cancer colon from normal controls (group III). Conclusion: CCSA-2 level in serum was significantly higher in cancer colon. Chromoendoscopy has a role in the detection of polyps, both neoplastic and non-neoplastic.
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spelling pubmed-74993502020-10-09 Comparative Evaluation of Colon Cancer Specific Antigen-2 Test and Chromocolonoscopy for Early Detection of Egyptian Patients with Colorectal Cancer Elhossary, Marwa Hawash, Nehah Badawi, Rehab Yousef, Mohamed Abd-Elsalam, Sherief Elhendawy, Mohammed Wasfy, Rania Abou-Saif, Sabry ElBendary, Amal Ismail, Saber Antiinflamm Antiallergy Agents Med Chem Article Background: Effective screening of colorectal cancer (CRC) in early stage could reduce the advancement of CRC and therefore mortality. Effective screening is based on either stool dependent tests or colon dependent examination. Aims: The aim of the study was a comparative evaluation of chromocolonoscopy and Colon Cancer-Specific Antigen-2 test for early detection of colorectal cancer in Egyptian patients. Methods: This case control study was carried out on 55 patients classified into 3 groups: Group I consisted of twenty patients with precancerous lesions detected by colonoscopy, Group II consisted of twenty patients diagnosed with colorectal cancer and Group III consisted of fifteen individuals (who underwent colonoscopy for other indications) as a control group. All the subjects were subjected to measure occult blood in the stool, measurement of Colon Cancer-Specific Antigen-2 level in serum and tissue and chromo colonoscopy using Indigo Carmine stain. Results: In group II, there was a statistically significant increase in CCSA2 in serum as compared to the other 2 groups. Cutoff >11.3 CCSA2 in serum showed 65% sensitivity, 85% specificity, 81.2% PPV, 70.8% NPV and 70.3% accuracy in the differentiation of group II with cancer colon from group I with premalignant colonic lesions. A cutoff > 9.1 CCSA2 in serum showed 95% sensitivity, 46.67% specificity, 70.4% PPV, 87.5% NPV and 73.5% accuracy in differentiating group II with cancer colon from normal controls (group III). Conclusion: CCSA-2 level in serum was significantly higher in cancer colon. Chromoendoscopy has a role in the detection of polyps, both neoplastic and non-neoplastic. Bentham Science Publishers 2020 /pmc/articles/PMC7499350/ /pubmed/31241019 http://dx.doi.org/10.2174/1871523018666190625164100 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Elhossary, Marwa
Hawash, Nehah
Badawi, Rehab
Yousef, Mohamed
Abd-Elsalam, Sherief
Elhendawy, Mohammed
Wasfy, Rania
Abou-Saif, Sabry
ElBendary, Amal
Ismail, Saber
Comparative Evaluation of Colon Cancer Specific Antigen-2 Test and Chromocolonoscopy for Early Detection of Egyptian Patients with Colorectal Cancer
title Comparative Evaluation of Colon Cancer Specific Antigen-2 Test and Chromocolonoscopy for Early Detection of Egyptian Patients with Colorectal Cancer
title_full Comparative Evaluation of Colon Cancer Specific Antigen-2 Test and Chromocolonoscopy for Early Detection of Egyptian Patients with Colorectal Cancer
title_fullStr Comparative Evaluation of Colon Cancer Specific Antigen-2 Test and Chromocolonoscopy for Early Detection of Egyptian Patients with Colorectal Cancer
title_full_unstemmed Comparative Evaluation of Colon Cancer Specific Antigen-2 Test and Chromocolonoscopy for Early Detection of Egyptian Patients with Colorectal Cancer
title_short Comparative Evaluation of Colon Cancer Specific Antigen-2 Test and Chromocolonoscopy for Early Detection of Egyptian Patients with Colorectal Cancer
title_sort comparative evaluation of colon cancer specific antigen-2 test and chromocolonoscopy for early detection of egyptian patients with colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499350/
https://www.ncbi.nlm.nih.gov/pubmed/31241019
http://dx.doi.org/10.2174/1871523018666190625164100
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