Physicochemical Considerations of Tumor Selective Drug Delivery and 
Activity Confinement with Particular Reference to 1,2-Bis(Sulfonyl)-1-Alkylhydrazines Delivery

Hypoxic tumor cell sub-populations are highly resistant to radiotherapy and their presence frequently causes disease recurrence and death. Here, we described the physicochemical properties required to develop superior tumor-targeted hypoxia-activated modular prodrugs that liberate extremely short-li...

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Detalles Bibliográficos
Autores principales: Penketh, Philip, Williamson, Hugh, Shyam, Krishnamurthy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499353/
https://www.ncbi.nlm.nih.gov/pubmed/32342817
http://dx.doi.org/10.2174/1567201817666200427215044
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author Penketh, Philip
Williamson, Hugh
Shyam, Krishnamurthy
author_facet Penketh, Philip
Williamson, Hugh
Shyam, Krishnamurthy
author_sort Penketh, Philip
collection PubMed
description Hypoxic tumor cell sub-populations are highly resistant to radiotherapy and their presence frequently causes disease recurrence and death. Here, we described the physicochemical properties required to develop superior tumor-targeted hypoxia-activated modular prodrugs that liberate extremely short-lived bis(sulfonyl)hydrazines (BSHs) as reactive cytotoxins, thereby precisely focusing cytotoxic stress on these radio-resistant hypoxic sub-populations. Therefore, cytotoxic stress will be focused on radiation resistant areas and thus strongly synergizing with radiotherapy.
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spelling pubmed-74993532020-10-09 Physicochemical Considerations of Tumor Selective Drug Delivery and 
Activity Confinement with Particular Reference to 1,2-Bis(Sulfonyl)-1-Alkylhydrazines Delivery Penketh, Philip Williamson, Hugh Shyam, Krishnamurthy Curr Drug Deliv Article Hypoxic tumor cell sub-populations are highly resistant to radiotherapy and their presence frequently causes disease recurrence and death. Here, we described the physicochemical properties required to develop superior tumor-targeted hypoxia-activated modular prodrugs that liberate extremely short-lived bis(sulfonyl)hydrazines (BSHs) as reactive cytotoxins, thereby precisely focusing cytotoxic stress on these radio-resistant hypoxic sub-populations. Therefore, cytotoxic stress will be focused on radiation resistant areas and thus strongly synergizing with radiotherapy. Bentham Science Publishers 2020-05 2020-05 /pmc/articles/PMC7499353/ /pubmed/32342817 http://dx.doi.org/10.2174/1567201817666200427215044 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Penketh, Philip
Williamson, Hugh
Shyam, Krishnamurthy
Physicochemical Considerations of Tumor Selective Drug Delivery and 
Activity Confinement with Particular Reference to 1,2-Bis(Sulfonyl)-1-Alkylhydrazines Delivery
title Physicochemical Considerations of Tumor Selective Drug Delivery and 
Activity Confinement with Particular Reference to 1,2-Bis(Sulfonyl)-1-Alkylhydrazines Delivery
title_full Physicochemical Considerations of Tumor Selective Drug Delivery and 
Activity Confinement with Particular Reference to 1,2-Bis(Sulfonyl)-1-Alkylhydrazines Delivery
title_fullStr Physicochemical Considerations of Tumor Selective Drug Delivery and 
Activity Confinement with Particular Reference to 1,2-Bis(Sulfonyl)-1-Alkylhydrazines Delivery
title_full_unstemmed Physicochemical Considerations of Tumor Selective Drug Delivery and 
Activity Confinement with Particular Reference to 1,2-Bis(Sulfonyl)-1-Alkylhydrazines Delivery
title_short Physicochemical Considerations of Tumor Selective Drug Delivery and 
Activity Confinement with Particular Reference to 1,2-Bis(Sulfonyl)-1-Alkylhydrazines Delivery
title_sort physicochemical considerations of tumor selective drug delivery and 
activity confinement with particular reference to 1,2-bis(sulfonyl)-1-alkylhydrazines delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499353/
https://www.ncbi.nlm.nih.gov/pubmed/32342817
http://dx.doi.org/10.2174/1567201817666200427215044
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