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Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties
Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens are planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety. Psoralen has been known for a wide spectrum of biological activities, spanning from cytotoxic, photosensitizing, insecticidal, anti...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bentham Science Publishers
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499361/ https://www.ncbi.nlm.nih.gov/pubmed/31241020 http://dx.doi.org/10.2174/1871523018666190625170802 |
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author | Jamalis, Joazaizulfazli Yusof, Faten Syahira Mohamed Chander, Subhash Wahab, Roswanira Abd. Bhagwat, Deepak P. Sankaranarayanan, Murugesan Almalki, Faisal Ben Hadda, Taibi |
author_facet | Jamalis, Joazaizulfazli Yusof, Faten Syahira Mohamed Chander, Subhash Wahab, Roswanira Abd. Bhagwat, Deepak P. Sankaranarayanan, Murugesan Almalki, Faisal Ben Hadda, Taibi |
author_sort | Jamalis, Joazaizulfazli |
collection | PubMed |
description | Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens are planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety. Psoralen has been known for a wide spectrum of biological activities, spanning from cytotoxic, photosensitizing, insecticidal, antibacterial to antifungal effect. Thus, several structural changes were introduced to explore the role of specific positions with respect to the biological activity. Convenient approaches utilized for the synthesis of psoralen skeleton can be categorized into two parts: (i) the preparation of the tricyclic ring system from resorcinol, (ii) the exocyclic modification of the intact ring system. Furthermore, although psoralens have been used in diverse ways, we mainly focus in this work on their clinical utility for the treatment of psioraisis, vitiligo and skin-related disorder. |
format | Online Article Text |
id | pubmed-7499361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-74993612020-10-09 Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties Jamalis, Joazaizulfazli Yusof, Faten Syahira Mohamed Chander, Subhash Wahab, Roswanira Abd. Bhagwat, Deepak P. Sankaranarayanan, Murugesan Almalki, Faisal Ben Hadda, Taibi Antiinflamm Antiallergy Agents Med Chem Article Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens are planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety. Psoralen has been known for a wide spectrum of biological activities, spanning from cytotoxic, photosensitizing, insecticidal, antibacterial to antifungal effect. Thus, several structural changes were introduced to explore the role of specific positions with respect to the biological activity. Convenient approaches utilized for the synthesis of psoralen skeleton can be categorized into two parts: (i) the preparation of the tricyclic ring system from resorcinol, (ii) the exocyclic modification of the intact ring system. Furthermore, although psoralens have been used in diverse ways, we mainly focus in this work on their clinical utility for the treatment of psioraisis, vitiligo and skin-related disorder. Bentham Science Publishers 2020-09 2020-09 /pmc/articles/PMC7499361/ /pubmed/31241020 http://dx.doi.org/10.2174/1871523018666190625170802 Text en © 2020 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Jamalis, Joazaizulfazli Yusof, Faten Syahira Mohamed Chander, Subhash Wahab, Roswanira Abd. Bhagwat, Deepak P. Sankaranarayanan, Murugesan Almalki, Faisal Ben Hadda, Taibi Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties |
title | Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties |
title_full | Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties |
title_fullStr | Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties |
title_full_unstemmed | Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties |
title_short | Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties |
title_sort | psoralen derivatives: recent advances of synthetic strategy and pharmacological properties |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499361/ https://www.ncbi.nlm.nih.gov/pubmed/31241020 http://dx.doi.org/10.2174/1871523018666190625170802 |
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