Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1

Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19’s pathogenesis and progression to severity. Here we dem...

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Autores principales: Sierra, Beatriz, Pérez, Ana B, Aguirre, Eglis, Bracho, Claudia, Valdés, Odalys, Jimenez, Narciso, Baldoquin, Waldemar, Gonzalez, Guelsys, Ortega, Lilia M, Montalvo, Maria C, Resik, Sonia, Alvarez, Delmis, Guzmán, Maria G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499702/
https://www.ncbi.nlm.nih.gov/pubmed/33123608
http://dx.doi.org/10.1093/ofid/ofaa407
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author Sierra, Beatriz
Pérez, Ana B
Aguirre, Eglis
Bracho, Claudia
Valdés, Odalys
Jimenez, Narciso
Baldoquin, Waldemar
Gonzalez, Guelsys
Ortega, Lilia M
Montalvo, Maria C
Resik, Sonia
Alvarez, Delmis
Guzmán, Maria G
author_facet Sierra, Beatriz
Pérez, Ana B
Aguirre, Eglis
Bracho, Claudia
Valdés, Odalys
Jimenez, Narciso
Baldoquin, Waldemar
Gonzalez, Guelsys
Ortega, Lilia M
Montalvo, Maria C
Resik, Sonia
Alvarez, Delmis
Guzmán, Maria G
author_sort Sierra, Beatriz
collection PubMed
description Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19’s pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome.
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spelling pubmed-74997022020-09-21 Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1 Sierra, Beatriz Pérez, Ana B Aguirre, Eglis Bracho, Claudia Valdés, Odalys Jimenez, Narciso Baldoquin, Waldemar Gonzalez, Guelsys Ortega, Lilia M Montalvo, Maria C Resik, Sonia Alvarez, Delmis Guzmán, Maria G Open Forum Infect Dis Brief Reports Early recognition of severe forms of coronavirus disease 2019 (COVID-19) is essential for an opportune and effective intervention, reducing life-risking complications. An altered inflammatory immune response seems to be associated with COVID-19’s pathogenesis and progression to severity. Here we demonstrate the utility of early nasopharyngeal swab samples for detection of the early expression of immune markers and the potential value of CCL2/MCP-1 in predicting disease outcome. Oxford University Press 2020-09-03 /pmc/articles/PMC7499702/ /pubmed/33123608 http://dx.doi.org/10.1093/ofid/ofaa407 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Sierra, Beatriz
Pérez, Ana B
Aguirre, Eglis
Bracho, Claudia
Valdés, Odalys
Jimenez, Narciso
Baldoquin, Waldemar
Gonzalez, Guelsys
Ortega, Lilia M
Montalvo, Maria C
Resik, Sonia
Alvarez, Delmis
Guzmán, Maria G
Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1
title Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1
title_full Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1
title_fullStr Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1
title_full_unstemmed Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1
title_short Association of Early Nasopharyngeal Immune Markers With COVID-19 Clinical Outcome: Predictive Value of CCL2/MCP-1
title_sort association of early nasopharyngeal immune markers with covid-19 clinical outcome: predictive value of ccl2/mcp-1
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7499702/
https://www.ncbi.nlm.nih.gov/pubmed/33123608
http://dx.doi.org/10.1093/ofid/ofaa407
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