m6A modification in RNA: biogenesis, functions and roles in gliomas

The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the most abundant form of posttranscriptional RNA modification in eukaryotes. Through the develop...

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Autores principales: Zhang, Yuhao, Geng, Xiuchao, Li, Qiang, Xu, Jianglong, Tan, Yanli, Xiao, Menglin, Song, Jia, Liu, Fulin, Fang, Chuan, Wang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500025/
https://www.ncbi.nlm.nih.gov/pubmed/32943100
http://dx.doi.org/10.1186/s13046-020-01706-8
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author Zhang, Yuhao
Geng, Xiuchao
Li, Qiang
Xu, Jianglong
Tan, Yanli
Xiao, Menglin
Song, Jia
Liu, Fulin
Fang, Chuan
Wang, Hong
author_facet Zhang, Yuhao
Geng, Xiuchao
Li, Qiang
Xu, Jianglong
Tan, Yanli
Xiao, Menglin
Song, Jia
Liu, Fulin
Fang, Chuan
Wang, Hong
author_sort Zhang, Yuhao
collection PubMed
description The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the most abundant form of posttranscriptional RNA modification in eukaryotes. Through the development of m6A RNA sequencing, the relevant molecular mechanism of m6A modification has gradually been revealed. It has been found that the effect of m6A modification on RNA metabolism involves processing, nuclear export, translation and even decay. As the most common malignant tumour of the central nervous system, gliomas (especially glioblastoma) have a very poor prognosis, and treatment efficacy is not ideal even with the application of high-intensity treatment measures of surgery combined with chemoradiotherapy. Exploring the origin and development mechanisms of tumour cells from the perspective of tumour biogenesis has always been a hotspot in the field of glioma research. Emerging evidence suggests that m6A modification can play a key role in gliomas through a variety of mechanisms, providing more possibilities for early diagnosis and targeted therapy of gliomas. The aim of the present review is to focus on the research progress regarding the association between m6A modification and gliomas. And to provide a theoretical basis according to the currently available literature for further exploring this association. This review may provide new insights for the molecular mechanism, early diagnosis, histologic grading, targeted therapy and prognostic evaluation of gliomas.
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spelling pubmed-75000252020-09-21 m6A modification in RNA: biogenesis, functions and roles in gliomas Zhang, Yuhao Geng, Xiuchao Li, Qiang Xu, Jianglong Tan, Yanli Xiao, Menglin Song, Jia Liu, Fulin Fang, Chuan Wang, Hong J Exp Clin Cancer Res Review The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the most abundant form of posttranscriptional RNA modification in eukaryotes. Through the development of m6A RNA sequencing, the relevant molecular mechanism of m6A modification has gradually been revealed. It has been found that the effect of m6A modification on RNA metabolism involves processing, nuclear export, translation and even decay. As the most common malignant tumour of the central nervous system, gliomas (especially glioblastoma) have a very poor prognosis, and treatment efficacy is not ideal even with the application of high-intensity treatment measures of surgery combined with chemoradiotherapy. Exploring the origin and development mechanisms of tumour cells from the perspective of tumour biogenesis has always been a hotspot in the field of glioma research. Emerging evidence suggests that m6A modification can play a key role in gliomas through a variety of mechanisms, providing more possibilities for early diagnosis and targeted therapy of gliomas. The aim of the present review is to focus on the research progress regarding the association between m6A modification and gliomas. And to provide a theoretical basis according to the currently available literature for further exploring this association. This review may provide new insights for the molecular mechanism, early diagnosis, histologic grading, targeted therapy and prognostic evaluation of gliomas. BioMed Central 2020-09-17 /pmc/articles/PMC7500025/ /pubmed/32943100 http://dx.doi.org/10.1186/s13046-020-01706-8 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Yuhao
Geng, Xiuchao
Li, Qiang
Xu, Jianglong
Tan, Yanli
Xiao, Menglin
Song, Jia
Liu, Fulin
Fang, Chuan
Wang, Hong
m6A modification in RNA: biogenesis, functions and roles in gliomas
title m6A modification in RNA: biogenesis, functions and roles in gliomas
title_full m6A modification in RNA: biogenesis, functions and roles in gliomas
title_fullStr m6A modification in RNA: biogenesis, functions and roles in gliomas
title_full_unstemmed m6A modification in RNA: biogenesis, functions and roles in gliomas
title_short m6A modification in RNA: biogenesis, functions and roles in gliomas
title_sort m6a modification in rna: biogenesis, functions and roles in gliomas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500025/
https://www.ncbi.nlm.nih.gov/pubmed/32943100
http://dx.doi.org/10.1186/s13046-020-01706-8
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