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Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging

BACKGROUND: Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease. RESULTS: To decipher connections between these processes, we create LostArc, an ultrasensit...

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Detalles Bibliográficos
Autores principales:	Lujan, Scott A., Longley, Matthew J., Humble, Margaret H., Lavender, Christopher A., Burkholder, Adam, Blakely, Emma L., Alston, Charlotte L., Gorman, Grainne S., Turnbull, Doug M., McFarland, Robert, Taylor, Robert W., Kunkel, Thomas A., Copeland, William C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500033/ https://www.ncbi.nlm.nih.gov/pubmed/32943091 http://dx.doi.org/10.1186/s13059-020-02138-5

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