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CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation

The costimulatory molecule CD226 is highly expressed on effector/memory T cells and natural killer cells. Costimulatory signals received by T cells can impact both central and peripheral tolerance mechanisms. Genetic polymorphisms in CD226 have been associated with susceptibility to type 1 diabetes...

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Detalles Bibliográficos
Autores principales:	Shapiro, Melanie R., Yeh, Wen-I, Longfield, Joshua R., Gallagher, John, Infante, Caridad M., Wellford, Sarah, Posgai, Amanda L., Atkinson, Mark A., Campbell-Thompson, Martha, Lieberman, Scott M., Serreze, David V., Geurts, Aron M., Chen, Yi-Guang, Brusko, Todd M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500101/ https://www.ncbi.nlm.nih.gov/pubmed/33013915 http://dx.doi.org/10.3389/fimmu.2020.02180

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