Fixation Preference for Visual and Auditory Targets in Monkeys with Strabismus

PURPOSE: During binocular viewing, many strabismic subjects choose the eye of fixation depending on the retinotopic location of a visual target. Here, we compare eye choice behavior when orienting to visual and non-visual (auditory) targets. METHODS: Eye movements were measured in two head-fixed exotropic strabismic monkeys in a saccadic task involving either a visual or an auditory stimulus (no visual target information or feedback) during monocular or binocular viewing. The stimulus was one of 21 visual or auditory targets arranged 10° apart in a 7 × 3 array at a distance of 57 cm in an otherwise dark room. Fixation preference was calculated by recording the incidence of using a specific eye to acquire the target at any location. RESULTS: Spatial patterns of fixation preference were observed in both monkeys for both visual and auditory stimuli; targets to the far right were acquired by the right eye, and targets to the far left were acquired by the left eye. For visual targets, the border for a change in fixation preference occurred in between the visual axes of the fixating and deviated eyes (variable in the two animals). In contrast, the border for fixation change remained near the cranio-center during the auditory task. During monocular viewing, fixation switching was observed only at the extremities during visual tasks; during the auditory task, fixation preference was similar to that observed during binocular viewing. CONCLUSIONS: Fixation preference persists for invisible auditory targets. Our data suggest that visual suppression could modify underlying eye choice behavior that functions independently from vision.