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The Role of Mitochondria in Vascular Calcification
Vascular calcification (VC) was defined as the ectopic deposition of calcium–phosphorus complexes on the blood vessel walls. It was a process involving multiple factors and mechanisms, covering the phenotype transition of vascular smooth muscle cells (VSMCs) and release of microvesicles. It was a co...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500121/ https://www.ncbi.nlm.nih.gov/pubmed/32983930 http://dx.doi.org/10.2478/jtim-2020-0013 |
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author | Wang, Pengbo Zhang, Naijin Wu, Boquan Wu, Shaojun Zhang, Ying Sun, Yingxian |
author_facet | Wang, Pengbo Zhang, Naijin Wu, Boquan Wu, Shaojun Zhang, Ying Sun, Yingxian |
author_sort | Wang, Pengbo |
collection | PubMed |
description | Vascular calcification (VC) was defined as the ectopic deposition of calcium–phosphorus complexes on the blood vessel walls. It was a process involving multiple factors and mechanisms, covering the phenotype transition of vascular smooth muscle cells (VSMCs) and release of microvesicles. It was a common end-stage alteration of chronic diseases such as cardiovascular disease and chronic kidney disease. Increasing evidence indicates that mitochondria were involved in the development of VC. Mitochondria provided energy to cells, maintained the stability of cell functions, and participated in a variety of biological behavior. Oxidative stress, autophagy, apoptosis, and mitochondrial DNA (mtDNA) damage could affect the development of VSMCs calcification by alteration of mitochondrial function. This article reviewed the mechanism of calcification and the role of mitochondria in VC, aiming to raise a novel insight into drug development and clinical treatment. |
format | Online Article Text |
id | pubmed-7500121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-75001212020-09-25 The Role of Mitochondria in Vascular Calcification Wang, Pengbo Zhang, Naijin Wu, Boquan Wu, Shaojun Zhang, Ying Sun, Yingxian J Transl Int Med Review Article Vascular calcification (VC) was defined as the ectopic deposition of calcium–phosphorus complexes on the blood vessel walls. It was a process involving multiple factors and mechanisms, covering the phenotype transition of vascular smooth muscle cells (VSMCs) and release of microvesicles. It was a common end-stage alteration of chronic diseases such as cardiovascular disease and chronic kidney disease. Increasing evidence indicates that mitochondria were involved in the development of VC. Mitochondria provided energy to cells, maintained the stability of cell functions, and participated in a variety of biological behavior. Oxidative stress, autophagy, apoptosis, and mitochondrial DNA (mtDNA) damage could affect the development of VSMCs calcification by alteration of mitochondrial function. This article reviewed the mechanism of calcification and the role of mitochondria in VC, aiming to raise a novel insight into drug development and clinical treatment. Sciendo 2020-06-30 /pmc/articles/PMC7500121/ /pubmed/32983930 http://dx.doi.org/10.2478/jtim-2020-0013 Text en © 2020 Pengbo Wang et al., published by Sciendo http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Review Article Wang, Pengbo Zhang, Naijin Wu, Boquan Wu, Shaojun Zhang, Ying Sun, Yingxian The Role of Mitochondria in Vascular Calcification |
title | The Role of Mitochondria in Vascular Calcification |
title_full | The Role of Mitochondria in Vascular Calcification |
title_fullStr | The Role of Mitochondria in Vascular Calcification |
title_full_unstemmed | The Role of Mitochondria in Vascular Calcification |
title_short | The Role of Mitochondria in Vascular Calcification |
title_sort | role of mitochondria in vascular calcification |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500121/ https://www.ncbi.nlm.nih.gov/pubmed/32983930 http://dx.doi.org/10.2478/jtim-2020-0013 |
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