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Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress

Ubiquitination is a modification after protein transcription that plays a vital role in maintaining the homeostasis of the cellular environment. The Homologous to E6AP C-terminus (HECT) family E3 ubiquitin ligases are a kind of E3 ubiquitin ligases with a C-terminal HECT domain that mediates the bin...

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Autores principales: Qian, Hao, Zhang, Ying, Wu, Boquan, Wu, Shaojun, You, Shilong, Zhang, Naijin, Sun, Yingxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sciendo 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500122/
https://www.ncbi.nlm.nih.gov/pubmed/32983929
http://dx.doi.org/10.2478/jtim-2020-0012
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author Qian, Hao
Zhang, Ying
Wu, Boquan
Wu, Shaojun
You, Shilong
Zhang, Naijin
Sun, Yingxian
author_facet Qian, Hao
Zhang, Ying
Wu, Boquan
Wu, Shaojun
You, Shilong
Zhang, Naijin
Sun, Yingxian
author_sort Qian, Hao
collection PubMed
description Ubiquitination is a modification after protein transcription that plays a vital role in maintaining the homeostasis of the cellular environment. The Homologous to E6AP C-terminus (HECT) family E3 ubiquitin ligases are a kind of E3 ubiquitin ligases with a C-terminal HECT domain that mediates the binding of ubiquitin to substrate proteins and a variable-length N-terminal extension. HECT-ubiquitinated ligases can be divided into three categories: NEDD4 superfamily, HERC superfamily, and other HECT superfamilies. HECT ubiquitin ligase plays an essential role in the development of many human diseases. In this review, we focus on the physiological and pathological processes involved in oxidative stress and the role of E3 ubiquitin ligase of the HECT family.
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spelling pubmed-75001222020-09-25 Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress Qian, Hao Zhang, Ying Wu, Boquan Wu, Shaojun You, Shilong Zhang, Naijin Sun, Yingxian J Transl Int Med Review Article Ubiquitination is a modification after protein transcription that plays a vital role in maintaining the homeostasis of the cellular environment. The Homologous to E6AP C-terminus (HECT) family E3 ubiquitin ligases are a kind of E3 ubiquitin ligases with a C-terminal HECT domain that mediates the binding of ubiquitin to substrate proteins and a variable-length N-terminal extension. HECT-ubiquitinated ligases can be divided into three categories: NEDD4 superfamily, HERC superfamily, and other HECT superfamilies. HECT ubiquitin ligase plays an essential role in the development of many human diseases. In this review, we focus on the physiological and pathological processes involved in oxidative stress and the role of E3 ubiquitin ligase of the HECT family. Sciendo 2020-06-30 /pmc/articles/PMC7500122/ /pubmed/32983929 http://dx.doi.org/10.2478/jtim-2020-0012 Text en © 2020 Hao Qian et al., published by Sciendo http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Review Article
Qian, Hao
Zhang, Ying
Wu, Boquan
Wu, Shaojun
You, Shilong
Zhang, Naijin
Sun, Yingxian
Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress
title Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress
title_full Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress
title_fullStr Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress
title_full_unstemmed Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress
title_short Structure and Function of HECT E3 Ubiquitin Ligases and their Role in Oxidative Stress
title_sort structure and function of hect e3 ubiquitin ligases and their role in oxidative stress
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500122/
https://www.ncbi.nlm.nih.gov/pubmed/32983929
http://dx.doi.org/10.2478/jtim-2020-0012
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