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TNFα and IL-17 alkalinize airway surface liquid through CFTR and pendrin

The pH of airway surface liquid (ASL) is a key factor that determines respiratory host defense; ASL acidification impairs and alkalinization enhances key defense mechanisms. Under healthy conditions, airway epithelia secrete base ([Formula: see text]) and acid (H(+)) to control ASL pH (pH(ASL)). Neu...

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Detalles Bibliográficos
Autores principales:	Rehman, Tayyab, Thornell, Ian M., Pezzulo, Alejandro A., Thurman, Andrew L., Romano Ibarra, Guillermo S., Karp, Philip H., Tan, Ping, Duffey, Michael E., Welsh, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Physiological Society 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500220/ https://www.ncbi.nlm.nih.gov/pubmed/32432926 http://dx.doi.org/10.1152/ajpcell.00112.2020

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