Cargando…

Integrative omics analysis identifies macrophage migration inhibitory factor signaling pathways underlying human hepatic fibrogenesis and fibrosis

The genetic basis underlying liver fibrosis remains largely unknown. We conducted a study to identify genetic alleles and underlying pathways associated with hepatic fibrogenesis and fibrosis at the genome-wide level in 121 human livers. By accepting a liberal significance level of P<1e-4, we ide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Zhipeng, Chalasani, Naga, Lin, Jingmei, Gawrieh, Samer, He, Yuan, Tseng, Yan J., Liu, Wanqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500331/ https://www.ncbi.nlm.nih.gov/pubmed/32953199 http://dx.doi.org/10.1097/jbr.0000000000000026

Ejemplares similares

GDF8 Contributes to Liver Fibrogenesis and Concomitant Skeletal Muscle Wasting
por: Culver, Alexander, et al.
Publicado: (2023)

Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans
por: Beljaars, Leonie, et al.
Publicado: (2014)

Dynamic Alterations to Hepatic MicroRNA-29a in Response to Long-Term High-Fat Diet and EtOH Feeding
por: Liang, Tiebing, et al.
Publicado: (2023)

Characterization of the Roles of Vimentin in Regulating the Proliferation and Migration of HSCs during Hepatic Fibrogenesis
por: Wang, Pei-Wen, et al.
Publicado: (2019)

Transcriptional regulation of PNPLA3 and its impact on susceptibility to nonalcoholic fatty liver Disease (NAFLD) in humans
por: Liu, Wanqing, et al.
Publicado: (2016)

Role of macrophages in liver cirrhosis: fibrogenesis and resolution
por: Elsherif, Sherine Ahmed, et al.
Publicado: (2022)

Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre-disposition pending between fiction and reality
por: Gressner, OA, et al.
Publicado: (2007)

Berberine Inhibition of Fibrogenesis in a Rat Model of Liver Fibrosis and in Hepatic Stellate Cells
por: Wang, Ning, et al.
Publicado: (2016)

The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis
por: Bansal, Ruchi, et al.
Publicado: (2015)

FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis
por: Liu, Cong, et al.
Publicado: (2023)

Changing Trends of Cirrhotic and Noncirrhotic Hepatocellular Carcinoma in the Era of Directly-Acting Antiviral Agents
por: Mathur, Karan, et al.
Publicado: (2021)

Expression of angiotensinogen during hepatic fibrogenesis and its effect on hepatic stellate cells
por: Lu, Ping, et al.
Publicado: (2011)

Fibrogenesis
por: Harington, J. S.
Publicado: (1974)

Fibrogenesis
por: Munger, John S., et al.
Publicado: (2010)

Macrophage‐derived HMGB1 is dispensable for tissue fibrogenesis
por: Personnaz, Jean, et al.
Publicado: (2019)

Chronic hepatitis C infection–induced liver fibrogenesis is associated with M2 macrophage activation
por: Bility, Moses T., et al.
Publicado: (2016)

Automated assessment of steatosis in murine fatty liver
por: Sethunath, Deepak, et al.
Publicado: (2018)

Glycogenosis is common in nonalcoholic fatty liver disease and is independently associated with ballooning, but lower steatosis and lower fibrosis
por: Allende, Daniela S, et al.
Publicado: (2021)

Racial Disparities in Liver Transplantation for Hepatocellular Carcinoma Are Not Explained by Differences in Comorbidities, Liver Disease Severity, or Tumor Burden
por: Dakhoul, Lara, et al.
Publicado: (2018)

Macrophage migration inhibitory factor in acute kidneyinjury
por: Du, Yiwei, et al.
Publicado: (2022)

Genetic Variants in the Promoter Region of the Macrophage Migration Inhibitory Factor are Associated with the Severity of Hepatitis C Virus-Induced Liver Fibrosis
por: Wirtz, Theresa Hildegard, et al.
Publicado: (2019)

Redox mechanisms in hepatic chronic wound healing and fibrogenesis
por: Novo, Erica, et al.
Publicado: (2008)

NADPH oxidase mediated oxidative stress in hepatic fibrogenesis
por: Paik, Yong-Han, et al.
Publicado: (2011)

Role of Metabolism in Hepatic Stellate Cell Activation and Fibrogenesis
por: Hou, Wei, et al.
Publicado: (2018)

RSPOs facilitated HSC activation and promoted hepatic fibrogenesis
por: Yin, Xinguang, et al.
Publicado: (2016)

Inflammation and Fibrogenesis in MAFLD: Role of the Hepatic Immune System
por: Torre, Pietro, et al.
Publicado: (2021)

Phosphatidylethanolamines Are Associated with Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Adults and Induce Liver Cell Metabolic Perturbations and Hepatic Stellate Cell Activation
por: Shama, Samaa, et al.
Publicado: (2023)

Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPARα‐FGF21 Axis
por: Athinarayanan, Shaminie, et al.
Publicado: (2020)

Distinctive Features and Outcomes of Hepatocellular Carcinoma in Patients With Alcohol-Related Liver Disease: A US Multicenter Study
por: deLemos, Andrew, et al.
Publicado: (2020)

The Ultrastructure of Hepatic Stellate Cell–Macrophage Intercellular Crosstalk as a New Morphological Insight into Phenomenon of Fibrogenesis in Pediatric Autoimmune Hepatitis
por: Łotowska, Joanna Maria, et al.
Publicado: (2023)

Macrophage migration inhibitory factor regulates joint capsule fibrosis by promoting TGF-β1 production in fibroblasts
por: Zhang, Yuxin, et al.
Publicado: (2021)

The role of redox mechanisms in hepatic chronic wound healing and fibrogenesis
por: Novo, Erica, et al.
Publicado: (2012)

Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors
por: Schumacher, Justin D., et al.
Publicado: (2016)

TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice
por: Thiele, Nina D., et al.
Publicado: (2017)

Pathophysiological Roles of Ductular Reaction in Liver Inflammation and Hepatic Fibrogenesis
por: Sato, Keisaku, et al.
Publicado: (2022)

Polymorphism in Macrophage Migration Inhibitory Factor -173GC in Pediatric Patients with Autoimmune Hepatitis
por: Alsayed, Mona Abdel Latif, et al.
Publicado: (2020)

Severe Alcohol‐Associated Hepatitis Is Associated With Worse Survival in Critically Ill Patients With Acute on Chronic Liver Failure
por: Patidar, Kavish R., et al.
Publicado: (2021)

LILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis
por: Li, Dan-Pei, et al.
Publicado: (2023)

Altered AKAP12 expression in portal fibroblasts and liver sinusoids mediates transition from hepatic fibrogenesis to fibrosis resolution
por: Lee, Hye Shin, et al.
Publicado: (2018)

GLUCOCORTICOID SUPPRESSION OF MACROPHAGE MIGRATION INHIBITORY FACTOR
por: Balow, James E., et al.
Publicado: (1973)

Cannot write session to /tmp/vufind_sessions/sess_rd6u5arqic919tbgk5q3l3lsei