Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism

Epilepsy is a chronic brain dysfunction induced by an abnormal neuronal discharge that is caused by complicated psychopathologies. Recently, accumulating studies have revealed a close relationship between inflammation and epilepsy. Specifically, microglia and astrocytes are important inflammatory ce...

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Detalles Bibliográficos
Autores principales: Chen, Lu, Zhu, Lin, Lu, Di, Wu, Zhe, Han, Yanbing, Xu, Puying, Chang, Lvhua, Wu, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500526/
https://www.ncbi.nlm.nih.gov/pubmed/33013320
http://dx.doi.org/10.3389/fnmol.2020.554547
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author Chen, Lu
Zhu, Lin
Lu, Di
Wu, Zhe
Han, Yanbing
Xu, Puying
Chang, Lvhua
Wu, Qian
author_facet Chen, Lu
Zhu, Lin
Lu, Di
Wu, Zhe
Han, Yanbing
Xu, Puying
Chang, Lvhua
Wu, Qian
author_sort Chen, Lu
collection PubMed
description Epilepsy is a chronic brain dysfunction induced by an abnormal neuronal discharge that is caused by complicated psychopathologies. Recently, accumulating studies have revealed a close relationship between inflammation and epilepsy. Specifically, microglia and astrocytes are important inflammatory cells in the central nervous system (CNS) that have been proven to be related to the pathogenesis and development of epilepsy. Additionally, interleukin 4 (IL-4) is an anti-inflammatory factor that can regulate microglia and astrocytes in many aspects. This review article focuses on the regulatory role of IL-4 in the pathological changes of glial cells related to epilepsy. We additionally propose that IL-4 may play a protective role in epileptogenesis and suggest that IL-4 may be a novel therapeutic target for the treatment of epilepsy.
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spelling pubmed-75005262020-10-02 Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism Chen, Lu Zhu, Lin Lu, Di Wu, Zhe Han, Yanbing Xu, Puying Chang, Lvhua Wu, Qian Front Mol Neurosci Neuroscience Epilepsy is a chronic brain dysfunction induced by an abnormal neuronal discharge that is caused by complicated psychopathologies. Recently, accumulating studies have revealed a close relationship between inflammation and epilepsy. Specifically, microglia and astrocytes are important inflammatory cells in the central nervous system (CNS) that have been proven to be related to the pathogenesis and development of epilepsy. Additionally, interleukin 4 (IL-4) is an anti-inflammatory factor that can regulate microglia and astrocytes in many aspects. This review article focuses on the regulatory role of IL-4 in the pathological changes of glial cells related to epilepsy. We additionally propose that IL-4 may play a protective role in epileptogenesis and suggest that IL-4 may be a novel therapeutic target for the treatment of epilepsy. Frontiers Media S.A. 2020-09-04 /pmc/articles/PMC7500526/ /pubmed/33013320 http://dx.doi.org/10.3389/fnmol.2020.554547 Text en Copyright © 2020 Chen, Zhu, Lu, Wu, Han, Xu, Chang and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Chen, Lu
Zhu, Lin
Lu, Di
Wu, Zhe
Han, Yanbing
Xu, Puying
Chang, Lvhua
Wu, Qian
Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism
title Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism
title_full Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism
title_fullStr Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism
title_full_unstemmed Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism
title_short Interleukin 4 Affects Epilepsy by Regulating Glial Cells: Potential and Possible Mechanism
title_sort interleukin 4 affects epilepsy by regulating glial cells: potential and possible mechanism
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500526/
https://www.ncbi.nlm.nih.gov/pubmed/33013320
http://dx.doi.org/10.3389/fnmol.2020.554547
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