Male-biased aganglionic megacolon in the TashT mouse model of Hirschsprung disease involves upregulation of p53 protein activity and Ddx3y gene expression

Hirschsprung disease (HSCR) is a complex genetic disorder of neural crest development resulting in incomplete formation of the enteric nervous system (ENS). This life-threatening neurocristopathy affects 1/5000 live births, with a currently unexplained male-biased ratio. To address this lack of know...

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Detalles Bibliográficos
Autores principales: Cardinal, Tatiana, Bergeron, Karl-Frédérik, Soret, Rodolphe, Souchkova, Ouliana, Faure, Christophe, Guillon, Amélina, Pilon, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500598/
https://www.ncbi.nlm.nih.gov/pubmed/32898154
http://dx.doi.org/10.1371/journal.pgen.1009008

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