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The female side of pharmacotherapy for ADHD—A systematic literature review

OBJECTIVE: This comprehensive review examined sex differences in prescription rates and efficacy or effectiveness of pharmacotherapy treatment in girls and women with attention deficit hyperactivity disorder (ADHD), while identifying gaps in the scientific knowledge on this topic. METHOD: A rigorous...

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Autores principales: Kok, Francien M., Groen, Yvonne, Fuermaier, Anselm B. M., Tucha, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500607/
https://www.ncbi.nlm.nih.gov/pubmed/32946507
http://dx.doi.org/10.1371/journal.pone.0239257
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author Kok, Francien M.
Groen, Yvonne
Fuermaier, Anselm B. M.
Tucha, Oliver
author_facet Kok, Francien M.
Groen, Yvonne
Fuermaier, Anselm B. M.
Tucha, Oliver
author_sort Kok, Francien M.
collection PubMed
description OBJECTIVE: This comprehensive review examined sex differences in prescription rates and efficacy or effectiveness of pharmacotherapy treatment in girls and women with attention deficit hyperactivity disorder (ADHD), while identifying gaps in the scientific knowledge on this topic. METHOD: A rigorous electronic database search was carried out in order to identify all published studies on female-specific effects of stimulants and non-stimulants in the treatment of ADHD. In total, 2672 studies were screened of which 21 studies (seven on prescription rates, 14 on effects of pharmacotherapy) met the inclusion criteria and were included for analysis. RESULTS: In all seven studies on ADHD prescription rates, girls received significantly less prescriptions than boys, a difference however no longer seen in adults with the exception of one study. Each of the 14 studies on effectiveness / efficacy found at least one sex-difference in the effects of ADHD pharmacotherapy. CONCLUSION: Several sex-differences are demonstrated in the prescription, usage and efficacy /effectiveness of both stimulant and non-stimulant ADHD pharmacotherapy. A single daily use of MPH may possibly not be optimal for girls with ADHD and ATX may be a promising medication for girls and women with ADHD. The robustness of this result requires further investigation.
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spelling pubmed-75006072020-09-24 The female side of pharmacotherapy for ADHD—A systematic literature review Kok, Francien M. Groen, Yvonne Fuermaier, Anselm B. M. Tucha, Oliver PLoS One Research Article OBJECTIVE: This comprehensive review examined sex differences in prescription rates and efficacy or effectiveness of pharmacotherapy treatment in girls and women with attention deficit hyperactivity disorder (ADHD), while identifying gaps in the scientific knowledge on this topic. METHOD: A rigorous electronic database search was carried out in order to identify all published studies on female-specific effects of stimulants and non-stimulants in the treatment of ADHD. In total, 2672 studies were screened of which 21 studies (seven on prescription rates, 14 on effects of pharmacotherapy) met the inclusion criteria and were included for analysis. RESULTS: In all seven studies on ADHD prescription rates, girls received significantly less prescriptions than boys, a difference however no longer seen in adults with the exception of one study. Each of the 14 studies on effectiveness / efficacy found at least one sex-difference in the effects of ADHD pharmacotherapy. CONCLUSION: Several sex-differences are demonstrated in the prescription, usage and efficacy /effectiveness of both stimulant and non-stimulant ADHD pharmacotherapy. A single daily use of MPH may possibly not be optimal for girls with ADHD and ATX may be a promising medication for girls and women with ADHD. The robustness of this result requires further investigation. Public Library of Science 2020-09-18 /pmc/articles/PMC7500607/ /pubmed/32946507 http://dx.doi.org/10.1371/journal.pone.0239257 Text en © 2020 Kok et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kok, Francien M.
Groen, Yvonne
Fuermaier, Anselm B. M.
Tucha, Oliver
The female side of pharmacotherapy for ADHD—A systematic literature review
title The female side of pharmacotherapy for ADHD—A systematic literature review
title_full The female side of pharmacotherapy for ADHD—A systematic literature review
title_fullStr The female side of pharmacotherapy for ADHD—A systematic literature review
title_full_unstemmed The female side of pharmacotherapy for ADHD—A systematic literature review
title_short The female side of pharmacotherapy for ADHD—A systematic literature review
title_sort female side of pharmacotherapy for adhd—a systematic literature review
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500607/
https://www.ncbi.nlm.nih.gov/pubmed/32946507
http://dx.doi.org/10.1371/journal.pone.0239257
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