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Compound 21, a two-edged sword with both DREADD-selective and off-target outcomes in rats
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) represent a technical revolution in integrative neuroscience. However, the first used ligands exhibited dose-dependent selectivity for their molecular target, leading to potential unspecific effects. Compound 21 (C21) was recently...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500623/ https://www.ncbi.nlm.nih.gov/pubmed/32946510 http://dx.doi.org/10.1371/journal.pone.0238156 |