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mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia

Multiple lines of evidence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia. Integral to PSD glutamatergic signaling is reciprocal interplay between GluN and mGluR5 signaling. We examined agonist-induced mGluR5 signaling in the postm...

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Detalles Bibliográficos
Autores principales:	Wang, Hoau-Yan, MacDonald, Mathew L., Borgmann-Winter, Karin E., Banerjee, Anamika, Sleiman, Patrick, Tom, Andrew, Khan, Amber, Lee, Kuo-Chieh, Roussos, Panos, Siegel, Steven J., Hemby, Scott E, Bilker, Warren B., Gur, Raquel E., Hahn, Chang-Gyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500805/ https://www.ncbi.nlm.nih.gov/pubmed/30214040 http://dx.doi.org/10.1038/s41380-018-0234-y

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