TbRAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing

Localization of Repressor Activator Protein 1 (RAP1) to the telomere is essential for its telomeric functions. RAP1 homologs either directly bind the duplex telomere DNA or interact with telomere-binding proteins. We find that Trypanosoma brucei RAP1 relies on a unique double-stranded DNA (dsDNA) bi...

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Detalles Bibliográficos
Autores principales: Afrin, Marjia, Gaurav, Amit Kumar, Yang, Xian, Pan, Xuehua, Zhao, Yanxiang, Li, Bibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500927/
https://www.ncbi.nlm.nih.gov/pubmed/32948591
http://dx.doi.org/10.1126/sciadv.abc4065

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