USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2

TET2 DNA dioxygenase is frequently mutated in human hematopoietic malignancies and functionally inactivated in many solid tumors through a nonmutational mechanism. We recently found that TET2 mediates the interferon-JAK-STAT pathway to stimulate chemokine expression and tumor infiltration of lymphoc...

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Detalles Bibliográficos
Autores principales: Chen, Lei-lei, Smith, Matthew D., Lv, Lei, Nakagawa, Tadashi, Li, Zhijun, Sun, Shao-Cong, Brown, Nicholas G., Xiong, Yue, Xu, Yan-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500937/
https://www.ncbi.nlm.nih.gov/pubmed/32948596
http://dx.doi.org/10.1126/sciadv.abc9730

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