Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots...

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Detalles Bibliográficos
Autores principales: Díaz-Alonso, Javier, Morishita, Wade, Incontro, Salvatore, Simms, Jeffrey, Holtzman, Julia, Gill, Michael, Mucke, Lennart, Malenka, Robert C, Nicoll, Roger A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500950/
https://www.ncbi.nlm.nih.gov/pubmed/32831170
http://dx.doi.org/10.7554/eLife.58042
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author Díaz-Alonso, Javier
Morishita, Wade
Incontro, Salvatore
Simms, Jeffrey
Holtzman, Julia
Gill, Michael
Mucke, Lennart
Malenka, Robert C
Nicoll, Roger A
author_facet Díaz-Alonso, Javier
Morishita, Wade
Incontro, Salvatore
Simms, Jeffrey
Holtzman, Julia
Gill, Michael
Mucke, Lennart
Malenka, Robert C
Nicoll, Roger A
author_sort Díaz-Alonso, Javier
collection PubMed
description We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.
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spelling pubmed-75009502020-09-21 Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit Díaz-Alonso, Javier Morishita, Wade Incontro, Salvatore Simms, Jeffrey Holtzman, Julia Gill, Michael Mucke, Lennart Malenka, Robert C Nicoll, Roger A eLife Neuroscience We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs. eLife Sciences Publications, Ltd 2020-08-24 /pmc/articles/PMC7500950/ /pubmed/32831170 http://dx.doi.org/10.7554/eLife.58042 Text en © 2020, Díaz-Alonso et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Díaz-Alonso, Javier
Morishita, Wade
Incontro, Salvatore
Simms, Jeffrey
Holtzman, Julia
Gill, Michael
Mucke, Lennart
Malenka, Robert C
Nicoll, Roger A
Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit
title Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit
title_full Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit
title_fullStr Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit
title_full_unstemmed Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit
title_short Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit
title_sort long-term potentiation is independent of the c-tail of the glua1 ampa receptor subunit
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500950/
https://www.ncbi.nlm.nih.gov/pubmed/32831170
http://dx.doi.org/10.7554/eLife.58042
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