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Utility of microminipigs for evaluating liver-mediated gene expression in the presence of neutralizing antibody against vector capsid
Adeno-associated virus (AAV) vectors can transduce hepatocytes efficiently in vivo in various animal species, including humans. Few reports, however, have examined the utility of pigs in gene therapy. Pigs are potentially useful in preclinical studies because of their anatomical and physiological si...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500982/ https://www.ncbi.nlm.nih.gov/pubmed/32066928 http://dx.doi.org/10.1038/s41434-020-0125-0 |