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Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study

OBJECTIVES: To determine risk factors for peripheral arterial disease (PAD) in elderly patients with Type-2 diabetes mellitus. METHODS: The elderly patients with Type-2 diabetes treated in the Central Hospital of Cangzhou were enrolled and divided into PAD group and non-PAD group between October 201...

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Autores principales: Shou, Zhang, Zhao, Yongcai, Zhang, Yan, Li, Shaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501018/
https://www.ncbi.nlm.nih.gov/pubmed/32968406
http://dx.doi.org/10.12669/pjms.36.6.2906
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author Shou, Zhang
Zhao, Yongcai
Zhang, Yan
Li, Shaoqing
author_facet Shou, Zhang
Zhao, Yongcai
Zhang, Yan
Li, Shaoqing
author_sort Shou, Zhang
collection PubMed
description OBJECTIVES: To determine risk factors for peripheral arterial disease (PAD) in elderly patients with Type-2 diabetes mellitus. METHODS: The elderly patients with Type-2 diabetes treated in the Central Hospital of Cangzhou were enrolled and divided into PAD group and non-PAD group between October 2016 and November 2019, The data of the patients including age, gender, body mass index, blood pressure, hemoglobin A1c, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, total cholesterol, triglyceride, white cell count, lymphocyte count, high-sensitivity C-reactive protein, uric acid as well as living habits and complications of Type-2 diabetes mellitus were recorded to determine the risk factors for PAD. RESULTS: One thousand four hundred seventy six (1476) patients were enrolled, in which 465 patients were included in group of PAD, and 1011 in non-PAD group. The univariate analysis revealed that the two groups significantly differed in age (p=0.003), course of T2DM (p=0.001), hypertension (p=0.006), smoking habits (p<0.001), hyperuricemia (p<0.01), high-sensitivity C-reactive protein (p<0.01), white cell count (p<0.001), lymphocyte count (p<0.001) and diabetic neuropathy (p<0.001). In the multivariate analysis, age (OR: 1.56, 95% CI: 1.21-1.89), smoking habit (OR: 1.37, 95% CI: 1.19-1.68), hypertension (OR: 1.44, 95% CI: 1.15-1.98), diabetic neuropathy (OR: 3.55, 95% CI: 2.14-4.29), high-sensitivity C-reactive protein (OR: 1.74, 95% CI: 1.39-2.61) and hyperuricemia (OR: 2.71, 95% CI: 1.66-3.87) were significant risk factors for PAD. CONCLUSIONS: Age, smoking habit, hypertension, diabetic neuropathy, high-sensitivity C-reactive protein and hyperuricemia were independent risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus.
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spelling pubmed-75010182020-09-22 Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study Shou, Zhang Zhao, Yongcai Zhang, Yan Li, Shaoqing Pak J Med Sci Original Article OBJECTIVES: To determine risk factors for peripheral arterial disease (PAD) in elderly patients with Type-2 diabetes mellitus. METHODS: The elderly patients with Type-2 diabetes treated in the Central Hospital of Cangzhou were enrolled and divided into PAD group and non-PAD group between October 2016 and November 2019, The data of the patients including age, gender, body mass index, blood pressure, hemoglobin A1c, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, total cholesterol, triglyceride, white cell count, lymphocyte count, high-sensitivity C-reactive protein, uric acid as well as living habits and complications of Type-2 diabetes mellitus were recorded to determine the risk factors for PAD. RESULTS: One thousand four hundred seventy six (1476) patients were enrolled, in which 465 patients were included in group of PAD, and 1011 in non-PAD group. The univariate analysis revealed that the two groups significantly differed in age (p=0.003), course of T2DM (p=0.001), hypertension (p=0.006), smoking habits (p<0.001), hyperuricemia (p<0.01), high-sensitivity C-reactive protein (p<0.01), white cell count (p<0.001), lymphocyte count (p<0.001) and diabetic neuropathy (p<0.001). In the multivariate analysis, age (OR: 1.56, 95% CI: 1.21-1.89), smoking habit (OR: 1.37, 95% CI: 1.19-1.68), hypertension (OR: 1.44, 95% CI: 1.15-1.98), diabetic neuropathy (OR: 3.55, 95% CI: 2.14-4.29), high-sensitivity C-reactive protein (OR: 1.74, 95% CI: 1.39-2.61) and hyperuricemia (OR: 2.71, 95% CI: 1.66-3.87) were significant risk factors for PAD. CONCLUSIONS: Age, smoking habit, hypertension, diabetic neuropathy, high-sensitivity C-reactive protein and hyperuricemia were independent risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus. Professional Medical Publications 2020 /pmc/articles/PMC7501018/ /pubmed/32968406 http://dx.doi.org/10.12669/pjms.36.6.2906 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Shou, Zhang
Zhao, Yongcai
Zhang, Yan
Li, Shaoqing
Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study
title Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study
title_full Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study
title_fullStr Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study
title_full_unstemmed Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study
title_short Risk factors for peripheral arterial disease in elderly patients with Type-2 diabetes mellitus: A clinical study
title_sort risk factors for peripheral arterial disease in elderly patients with type-2 diabetes mellitus: a clinical study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501018/
https://www.ncbi.nlm.nih.gov/pubmed/32968406
http://dx.doi.org/10.12669/pjms.36.6.2906
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