Cargando…

Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantation

BACKGROUND: Ex-vivo lung perfusion (EVLP) is an innovative platform for assessing donor lungs in the pre-transplant window. In this study, we demonstrate an extension of its utility by administering the anti-CD20 monoclonal antibody, Rituximab, during EVLP. We hypothesized that this would lead to ta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ku, Terrance J.Y., Ribeiro, Rafaela V.P., Ferreira, Victor H., Galasso, Marcos, Keshavjee, Shaf, Kumar, Deepali, Cypel, Marcelo, Humar, Atul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501077/ https://www.ncbi.nlm.nih.gov/pubmed/32950000 http://dx.doi.org/10.1016/j.ebiom.2020.102994

Ejemplares similares

Incidence of post-transplant cytomegalovirus viremia in patients receiving lungs after ex vivo lung perfusion
por: Ribeiro, Rafaela V.P., et al.
Publicado: (2023)

Ex vivo lung perfusion
por: Watanabe, Tatsuaki, et al.
Publicado: (2021)

Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion
por: Galasso, Marcos, et al.
Publicado: (2019)

Increased Arginase Expression and Decreased Nitric Oxide in Pig Donor Lungs after Normothermic Ex Vivo Lung Perfusion
por: Tavasoli, Farshad, et al.
Publicado: (2020)

When to consider lung transplantation for COVID-19
por: Cypel, Marcelo, et al.
Publicado: (2020)

Successful sequential transplantation of 2 single lungs from the same donor into 2 different recipients—use of standard cold preservation and 10 °C preservation
por: Barr, James, et al.
Publicado: (2022)

Lung transplantation for acute COVID-19: the Toronto Lung Transplant Program experience
por: Yeung, Jonathan C., et al.
Publicado: (2021)

La transplantation pulmonaire dans le contexte de la COVID-19 aiguë : l’expérience du Programme de transplantation pulmonaire de Toronto
por: Yeung, Jonathan C., et al.
Publicado: (2021)

Successful 3-day lung preservation using a cyclic normothermic ex vivo lung perfusion strategy
por: Ali, Aadil, et al.
Publicado: (2022)

Successful use of a hepatitis C viremic donor in pediatric bilateral lobar lung transplantation
por: Kawashima, Mitsuaki, et al.
Publicado: (2022)

Chronic Candida dubliniensis meningitis in a lung transplant recipient
por: Herrera, Sabina, et al.
Publicado: (2019)

Veno-venous ECMO as a platform to evaluate lung lavage and surfactant replacement therapy in an animal model of severe ARDS
por: Qaqish, Robert, et al.
Publicado: (2020)

Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation
por: Sage, Andrew T., et al.
Publicado: (2015)

Assessment of Acute Rejection in a Lung Transplant Recipient Using a Sentinel Skin Flap
por: Haykal, Siba, et al.
Publicado: (2023)

A novel pre-clinical strategy to deliver antimicrobial doses of inhaled nitric oxide
por: Michaelsen, Vinicius S., et al.
Publicado: (2021)

T-cell responses following Natural Influenza Infection or Vaccination in Solid Organ Transplant Recipients
por: L’Huillier, Arnaud G., et al.
Publicado: (2020)

Bone marrow-derived progenitor cells in end-stage lung disease patients
por: Gilpin, Sarah E, et al.
Publicado: (2013)

Sequential broncho-alveolar lavages reflect distinct pulmonary compartments: clinical and research implications in lung transplantation
por: Levy, Liran, et al.
Publicado: (2018)

A machine-learning approach to human ex vivo lung perfusion predicts transplantation outcomes and promotes organ utilization
por: Sage, Andrew T., et al.
Publicado: (2023)

Respiratory Viral Infections in Transplant and Oncology Patients
por: Kumar, Deepali, et al.
Publicado: (2010)

False Positive B-Cells Crossmatch after Prior Rituximab Exposure of the Kidney Donor
por: Desoutter, Judith, et al.
Publicado: (2016)

Acellular ex vivo lung perfusate silences pro-inflammatory signaling in human lung endothelial and epithelial cells
por: Jeon, Jamie E., et al.
Publicado: (2023)

Human organ repair centers: Fact or fiction?
por: Keshavjee, Shaf
Publicado: (2020)

De Novo Design and Development of a Nutrient-Rich Perfusate for Ex Vivo Lung Perfusion with Cell Culture Models
por: Huang, Lei, et al.
Publicado: (2023)

The Association Between Extravascular Lung Water and Critical Care Outcomes Following Bilateral Lung Transplantation
por: Munshi, Laveena, et al.
Publicado: (2022)

Engineered mesenchymal stromal cell therapy during human lung ex vivo lung perfusion is compromised by acidic lung microenvironment
por: Nykänen, Antti I., et al.
Publicado: (2021)

Protective Mechanical Ventilation in Organ Donors: A Lifesaving Maneuver
por: Teijeiro-Paradis, Ricardo, et al.
Publicado: (2020)

Clinical immune-monitoring strategies for predicting infection risk in solid organ transplantation
por: Fernández-Ruiz, Mario, et al.
Publicado: (2014)

The impact of concordance with a lung cancer diagnosis pathway guideline on treatment access in patients with stage IV lung cancer
por: Pattison, Andrew, et al.
Publicado: (2020)

Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion
por: Bojko, Barbara, et al.
Publicado: (2021)

Paucisymptomatic COVID-19 in lung transplant recipient following two doses of mRNA-1273 (Moderna) vaccine
por: Marinelli, Tina, et al.
Publicado: (2021)

Evaluating the Impact of Ex Vivo Lung Perfusion on Organ Transplantation: A Retrospective Cohort Study
por: Peel, John K., et al.
Publicado: (2023)

Pulmonary Bacterial Communities in Surgically Resected Noncystic Fibrosis Bronchiectasis Lungs Are Similar to Those in Cystic Fibrosis
por: Maughan, Heather, et al.
Publicado: (2012)

Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation
por: Cunningham, Peter S, et al.
Publicado: (2019)

Outcomes of patients with respiratory failure declined for extracorporeal membrane oxygenation: a prospective observational study
por: Teijeiro-Paradis, Ricardo, et al.
Publicado: (2023)

The role of surgery in the management of locally advanced and metastatic thymoma: a narrative review
por: Wagner, Catherine, et al.
Publicado: (2021)

Alpha-1 Antitrypsin for COVID-19 Treatment: Dual Role in Antiviral Infection and Anti-Inflammation
por: Yang, Chengliang, et al.
Publicado: (2020)

Ex Vivo Normothermic Perfusion Induces Donor-Derived Leukocyte Mobilization and Removal Prior to Renal Transplantation
por: Stone, John P., et al.
Publicado: (2016)

Development and characterization of an anti-rituximab monoclonal antibody panel
por: Tada, Minoru, et al.
Publicado: (2018)

Randomized Trial of a Third Dose of mRNA-1273 Vaccine in Transplant Recipients
por: Hall, Victoria G., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i1btb8kmjtsjvkkabqiu3ub0ip