Cargando…
A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study
PURPOSE: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. METHODS: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prost...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501135/ https://www.ncbi.nlm.nih.gov/pubmed/31705265 http://dx.doi.org/10.1007/s00394-019-02132-z |
| _version_ | 1783583993805930496 |
|---|---|
| author | Papadimitriou, Nikos Muller, David van den Brandt, Piet A. Geybels, Milan Patel, Chirag J. Gunter, Marc J. Lopez, David S. Key, Timothy J. Perez-Cornago, Aurora Ferrari, Pietro Vineis, Paolo Weiderpass, Elisabete Boeing, Heiner Agudo, Antonio Sánchez, María-José Overvad, Kim Kühn, Tilman Fortner, Renee T. Palli, Domenico Drake, Isabel Bjartell, Anders Santiuste, Carmen Bueno-de-Mesquita, Bas H. Krogh, Vittorio Tjønneland, Anne Lauritzen, Dorthe Furstrand Gurrea, Aurelio Barricarte Quirós, José Ramón Stattin, Pär Trichopoulou, Antonia Martimianaki, Georgia Karakatsani, Anna Thysell, Elin Johansson, Ingegerd Ricceri, Fulvio Tumino, Rosario Larrañaga, Nerea Khaw, Kay Tee Riboli, Elio Tzoulaki, Ioanna Tsilidis, Konstantinos K. |
| author_facet | Papadimitriou, Nikos Muller, David van den Brandt, Piet A. Geybels, Milan Patel, Chirag J. Gunter, Marc J. Lopez, David S. Key, Timothy J. Perez-Cornago, Aurora Ferrari, Pietro Vineis, Paolo Weiderpass, Elisabete Boeing, Heiner Agudo, Antonio Sánchez, María-José Overvad, Kim Kühn, Tilman Fortner, Renee T. Palli, Domenico Drake, Isabel Bjartell, Anders Santiuste, Carmen Bueno-de-Mesquita, Bas H. Krogh, Vittorio Tjønneland, Anne Lauritzen, Dorthe Furstrand Gurrea, Aurelio Barricarte Quirós, José Ramón Stattin, Pär Trichopoulou, Antonia Martimianaki, Georgia Karakatsani, Anna Thysell, Elin Johansson, Ingegerd Ricceri, Fulvio Tumino, Rosario Larrañaga, Nerea Khaw, Kay Tee Riboli, Elio Tzoulaki, Ioanna Tsilidis, Konstantinos K. |
| author_sort | Papadimitriou, Nikos |
| collection | PubMed |
| description | PURPOSE: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. METHODS: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). RESULTS: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. CONCLUSIONS: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00394-019-02132-z) contains supplementary material, which is available to authorized users. |
| format | Online Article Text |
| id | pubmed-7501135 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Springer Berlin Heidelberg |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-75011352020-10-01 A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study Papadimitriou, Nikos Muller, David van den Brandt, Piet A. Geybels, Milan Patel, Chirag J. Gunter, Marc J. Lopez, David S. Key, Timothy J. Perez-Cornago, Aurora Ferrari, Pietro Vineis, Paolo Weiderpass, Elisabete Boeing, Heiner Agudo, Antonio Sánchez, María-José Overvad, Kim Kühn, Tilman Fortner, Renee T. Palli, Domenico Drake, Isabel Bjartell, Anders Santiuste, Carmen Bueno-de-Mesquita, Bas H. Krogh, Vittorio Tjønneland, Anne Lauritzen, Dorthe Furstrand Gurrea, Aurelio Barricarte Quirós, José Ramón Stattin, Pär Trichopoulou, Antonia Martimianaki, Georgia Karakatsani, Anna Thysell, Elin Johansson, Ingegerd Ricceri, Fulvio Tumino, Rosario Larrañaga, Nerea Khaw, Kay Tee Riboli, Elio Tzoulaki, Ioanna Tsilidis, Konstantinos K. Eur J Nutr Original Contribution PURPOSE: The evidence from the literature regarding the association of dietary factors and risk of prostate cancer is inconclusive. METHODS: A nutrient-wide association study was conducted to systematically and comprehensively evaluate the associations between 92 foods or nutrients and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox proportional hazard regression models adjusted for total energy intake, smoking status, body mass index, physical activity, diabetes and education were used to estimate hazard ratios and 95% confidence intervals for standardized dietary intakes. As in genome-wide association studies, correction for multiple comparisons was applied using the false discovery rate (FDR < 5%) method and suggested results were replicated in an independent cohort, the Netherlands Cohort Study (NLCS). RESULTS: A total of 5916 and 3842 incident cases of prostate cancer were diagnosed during a mean follow-up of 14 and 20 years in EPIC and NLCS, respectively. None of the dietary factors was associated with the risk of total prostate cancer in EPIC (minimum FDR-corrected P, 0.37). Null associations were also observed by disease stage, grade and fatality, except for positive associations observed for intake of dry cakes/biscuits with low-grade and butter with aggressive prostate cancer, respectively, out of which the intake of dry cakes/biscuits was replicated in the NLCS. CONCLUSIONS: Our findings provide little support for an association for the majority of the 92 examined dietary factors and risk of prostate cancer. The association of dry cakes/biscuits with low-grade prostate cancer warrants further replication given the scarcity in the literature. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00394-019-02132-z) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2019-11-08 2020 /pmc/articles/PMC7501135/ /pubmed/31705265 http://dx.doi.org/10.1007/s00394-019-02132-z Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
| spellingShingle | Original Contribution Papadimitriou, Nikos Muller, David van den Brandt, Piet A. Geybels, Milan Patel, Chirag J. Gunter, Marc J. Lopez, David S. Key, Timothy J. Perez-Cornago, Aurora Ferrari, Pietro Vineis, Paolo Weiderpass, Elisabete Boeing, Heiner Agudo, Antonio Sánchez, María-José Overvad, Kim Kühn, Tilman Fortner, Renee T. Palli, Domenico Drake, Isabel Bjartell, Anders Santiuste, Carmen Bueno-de-Mesquita, Bas H. Krogh, Vittorio Tjønneland, Anne Lauritzen, Dorthe Furstrand Gurrea, Aurelio Barricarte Quirós, José Ramón Stattin, Pär Trichopoulou, Antonia Martimianaki, Georgia Karakatsani, Anna Thysell, Elin Johansson, Ingegerd Ricceri, Fulvio Tumino, Rosario Larrañaga, Nerea Khaw, Kay Tee Riboli, Elio Tzoulaki, Ioanna Tsilidis, Konstantinos K. A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study |
| title | A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study |
| title_full | A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study |
| title_fullStr | A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study |
| title_full_unstemmed | A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study |
| title_short | A nutrient-wide association study for risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition and the Netherlands Cohort Study |
| title_sort | nutrient-wide association study for risk of prostate cancer in the european prospective investigation into cancer and nutrition and the netherlands cohort study |
| topic | Original Contribution |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501135/ https://www.ncbi.nlm.nih.gov/pubmed/31705265 http://dx.doi.org/10.1007/s00394-019-02132-z |
| work_keys_str_mv | AT papadimitriounikos anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT mullerdavid anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT vandenbrandtpieta anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT geybelsmilan anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT patelchiragj anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT guntermarcj anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT lopezdavids anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT keytimothyj anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT perezcornagoaurora anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT ferraripietro anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT vineispaolo anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT weiderpasselisabete anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT boeingheiner anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT agudoantonio anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT sanchezmariajose anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT overvadkim anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT kuhntilman anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT fortnerreneet anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT pallidomenico anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT drakeisabel anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT bjartellanders anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT santiustecarmen anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT buenodemesquitabash anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT kroghvittorio anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT tjønnelandanne anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT lauritzendorthefurstrand anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT gurreaaureliobarricarte anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT quirosjoseramon anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT stattinpar anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT trichopoulouantonia anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT martimianakigeorgia anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT karakatsanianna anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT thysellelin anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT johanssoningegerd anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT riccerifulvio anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT tuminorosario anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT larranaganerea anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT khawkaytee anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT ribolielio anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT tzoulakiioanna anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT tsilidiskonstantinosk anutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT papadimitriounikos nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT mullerdavid nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT vandenbrandtpieta nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT geybelsmilan nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT patelchiragj nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT guntermarcj nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT lopezdavids nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT keytimothyj nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT perezcornagoaurora nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT ferraripietro nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT vineispaolo nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT weiderpasselisabete nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT boeingheiner nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT agudoantonio nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT sanchezmariajose nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT overvadkim nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT kuhntilman nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT fortnerreneet nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT pallidomenico nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT drakeisabel nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT bjartellanders nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT santiustecarmen nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT buenodemesquitabash nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT kroghvittorio nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT tjønnelandanne nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT lauritzendorthefurstrand nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT gurreaaureliobarricarte nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT quirosjoseramon nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT stattinpar nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT trichopoulouantonia nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT martimianakigeorgia nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT karakatsanianna nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT thysellelin nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT johanssoningegerd nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT riccerifulvio nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT tuminorosario nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT larranaganerea nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT khawkaytee nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT ribolielio nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT tzoulakiioanna nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy AT tsilidiskonstantinosk nutrientwideassociationstudyforriskofprostatecancerintheeuropeanprospectiveinvestigationintocancerandnutritionandthenetherlandscohortstudy |