Structural and mechanistic basis of capsule O-acetylation in Neisseria meningitidis serogroup A

O-Acetylation of the capsular polysaccharide (CPS) of Neisseria meningitidis serogroup A (NmA) is critical for the induction of functional immune responses, making this modification mandatory for CPS-based anti-NmA vaccines. Using comprehensive NMR studies, we demonstrate that O-acetylation stabiliz...

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Detalles Bibliográficos
Autores principales: Fiebig, Timm, Cramer, Johannes T., Bethe, Andrea, Baruch, Petra, Curth, Ute, Führing, Jana I., Buettner, Falk F. R., Vogel, Ulrich, Schubert, Mario, Fedorov, Roman, Mühlenhoff, Martina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501274/
https://www.ncbi.nlm.nih.gov/pubmed/32948778
http://dx.doi.org/10.1038/s41467-020-18464-y

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