An IMiD-induced SALL4 degron system for selective degradation of target proteins

Regulating the amount of proteins in living cells is a powerful approach for understanding the functions of the proteins. Immunomodulatory drugs (IMiDs) induce the degradation of neosubstrates by interacting with celebron (CRBN) in the cullin E3 ubiquitin ligase complex (CRL4(CRBN)). Here, we develo...

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Detalles Bibliográficos
Autores principales: Yamanaka, Satoshi, Shoya, Yuki, Matsuoka, Saya, Nishida-Fukuda, Hisayo, Shibata, Norio, Sawasaki, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501283/
https://www.ncbi.nlm.nih.gov/pubmed/32948804
http://dx.doi.org/10.1038/s42003-020-01240-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501283/
https://www.ncbi.nlm.nih.gov/pubmed/32948804
http://dx.doi.org/10.1038/s42003-020-01240-5

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