SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells

Glioblastoma cancer-stem like cells (GSCs) display marked resistance to ionizing radiation (IR), a standard of care for glioblastoma patients. Mechanisms underpinning radio-resistance of GSCs remain largely unknown. Chromatin state and the accessibility of DNA lesions to DNA repair machineries are c...

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Detalles Bibliográficos
Autores principales: Obara, Elisabeth Anne Adanma, Aguilar-Morante, Diana, Rasmussen, Rikke Darling, Frias, Alex, Vitting-Serup, Kristoffer, Lim, Yi Chieh, Elbæk, Kirstine Juul, Pedersen, Henriette, Vardouli, Lina, Jensen, Kamilla Ellermann, Skjoth-Rasmussen, Jane, Brennum, Jannick, Tuckova, Lucie, Strauss, Robert, Dinant, Christoffel, Bartek, Jiri, Hamerlik, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501306/
https://www.ncbi.nlm.nih.gov/pubmed/32948765
http://dx.doi.org/10.1038/s41467-020-18549-8

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