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Highly regioselective 1,3-dipolar cycloaddition of 3′-O-propargyl guanosine with nitrile oxide: An efficient method for the synthesis of guanosine containing isoxazole moiety

The 1,3-dipolar cycloaddition reaction of 3′-O-propargyl guanosine with various in-situ generated nitrile oxides in the presence of DMF as a solvent is described. It is noteworthy that the reaction is highly regioselective that affords biologically important guanosine containing isoxazole moiety in...

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Detalles Bibliográficos
Autores principales:	Shanmugasundaram, Muthian, Senthilvelan, Annamalai, Kore, Anilkumar R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501312/ https://www.ncbi.nlm.nih.gov/pubmed/32981977 http://dx.doi.org/10.1016/j.tetlet.2020.152464

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