Multi potent aromatic nano colloid: synthesis, characterization and applications

In this study the aromatic nanocolloids (CANCs) are synthesized using the noble metal silver by using Citronella extract and confirmed through physio chemical analysis. The synthesised CANCs were evaluated for its antimicrobial activity and antibiofilm activity against pathogenic biofilm forming E....

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Autores principales: Soundhararajan, Ranjani, Mohamed Sheik Meeran, Salman Al Farzi, Prakash, Shruthy Priya, Mohammad, Waseem, Kandasamy, Ruckmani, Srinivasan, Hemalatha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501372/
https://www.ncbi.nlm.nih.gov/pubmed/32946020
http://dx.doi.org/10.1186/s13568-020-01104-5
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author Soundhararajan, Ranjani
Mohamed Sheik Meeran, Salman Al Farzi
Prakash, Shruthy Priya
Mohammad, Waseem
Kandasamy, Ruckmani
Srinivasan, Hemalatha
author_facet Soundhararajan, Ranjani
Mohamed Sheik Meeran, Salman Al Farzi
Prakash, Shruthy Priya
Mohammad, Waseem
Kandasamy, Ruckmani
Srinivasan, Hemalatha
author_sort Soundhararajan, Ranjani
collection PubMed
description In this study the aromatic nanocolloids (CANCs) are synthesized using the noble metal silver by using Citronella extract and confirmed through physio chemical analysis. The synthesised CANCs were evaluated for its antimicrobial activity and antibiofilm activity against pathogenic biofilm forming E. coli. In addition, synthesized CANCs were evaluated for the expression of virulent genes encoding AmpC and CTX-M-15. The results confirmed that CANCs showed effective antimicrobial activity through its bacteriostatic, bactericidal and quorum quencher activity and downregulated CTX-M-15 gene. CANCs were validated as alternate to the commercial fungicides to control plant pathogenic fungi such as A. niger MTCC (281), Fusarium graminearum MTCC (2089) and F. udum MTCC (2204). Furthermore, analysis of CANCs on breast cancer (MCF-7) cells under in vitro condition showed that the cytotoxicity of CANCs is dose dependent. Thus, the multifunctional CANCs can be utilized as potential antimicrobial, antifungal and anticancer agent. [Image: see text]
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spelling pubmed-75013722020-10-01 Multi potent aromatic nano colloid: synthesis, characterization and applications Soundhararajan, Ranjani Mohamed Sheik Meeran, Salman Al Farzi Prakash, Shruthy Priya Mohammad, Waseem Kandasamy, Ruckmani Srinivasan, Hemalatha AMB Express Original Article In this study the aromatic nanocolloids (CANCs) are synthesized using the noble metal silver by using Citronella extract and confirmed through physio chemical analysis. The synthesised CANCs were evaluated for its antimicrobial activity and antibiofilm activity against pathogenic biofilm forming E. coli. In addition, synthesized CANCs were evaluated for the expression of virulent genes encoding AmpC and CTX-M-15. The results confirmed that CANCs showed effective antimicrobial activity through its bacteriostatic, bactericidal and quorum quencher activity and downregulated CTX-M-15 gene. CANCs were validated as alternate to the commercial fungicides to control plant pathogenic fungi such as A. niger MTCC (281), Fusarium graminearum MTCC (2089) and F. udum MTCC (2204). Furthermore, analysis of CANCs on breast cancer (MCF-7) cells under in vitro condition showed that the cytotoxicity of CANCs is dose dependent. Thus, the multifunctional CANCs can be utilized as potential antimicrobial, antifungal and anticancer agent. [Image: see text] Springer Berlin Heidelberg 2020-09-18 /pmc/articles/PMC7501372/ /pubmed/32946020 http://dx.doi.org/10.1186/s13568-020-01104-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Soundhararajan, Ranjani
Mohamed Sheik Meeran, Salman Al Farzi
Prakash, Shruthy Priya
Mohammad, Waseem
Kandasamy, Ruckmani
Srinivasan, Hemalatha
Multi potent aromatic nano colloid: synthesis, characterization and applications
title Multi potent aromatic nano colloid: synthesis, characterization and applications
title_full Multi potent aromatic nano colloid: synthesis, characterization and applications
title_fullStr Multi potent aromatic nano colloid: synthesis, characterization and applications
title_full_unstemmed Multi potent aromatic nano colloid: synthesis, characterization and applications
title_short Multi potent aromatic nano colloid: synthesis, characterization and applications
title_sort multi potent aromatic nano colloid: synthesis, characterization and applications
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501372/
https://www.ncbi.nlm.nih.gov/pubmed/32946020
http://dx.doi.org/10.1186/s13568-020-01104-5
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