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Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production

Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their genetic potential, including silent and metagenomic BGCs. Although the engineered Streptomyces coelicolor M1152 is a widely used host for heterologous expression of BGCs, a systemic understanding of how its genet...

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Detalles Bibliográficos
Autores principales:	Sulheim, Snorre, Kumelj, Tjaša, van Dissel, Dino, Salehzadeh-Yazdi, Ali, Du, Chao, van Wezel, Gilles P., Nieselt, Kay, Almaas, Eivind, Wentzel, Alexander, Kerkhoven, Eduard J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501462/ https://www.ncbi.nlm.nih.gov/pubmed/32942174 http://dx.doi.org/10.1016/j.isci.2020.101525

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