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Genetic Diversity of HIV-1 in Krasnoyarsk Krai: Area with High Levels of HIV-1 Recombination in Russia
More than a quarter of HIV-infected individuals registered in Russia live in Siberia. Unlike Central Russia where HIV-1 subtype A6 is predominant, in most Siberian regions since 2012, a new HIV-1 CRF63_02A1 genetic variant has spread, with the share of this variant attaining 75–85% among newly ident...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501552/ https://www.ncbi.nlm.nih.gov/pubmed/32964045 http://dx.doi.org/10.1155/2020/9057541 |
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author | Maksimenko, Lada V. Totmenin, Aleksey V. Gashnikova, Mariya P. Astakhova, Ekaterina M. Skudarnov, Sergey E. Ostapova, Tatyana S. Yaschenko, Svetlana V. Meshkov, Ivan O. Bocharov, Evgeniy F. Maksyutov, Rinat А. Gashnikova, Natalya M. |
author_facet | Maksimenko, Lada V. Totmenin, Aleksey V. Gashnikova, Mariya P. Astakhova, Ekaterina M. Skudarnov, Sergey E. Ostapova, Tatyana S. Yaschenko, Svetlana V. Meshkov, Ivan O. Bocharov, Evgeniy F. Maksyutov, Rinat А. Gashnikova, Natalya M. |
author_sort | Maksimenko, Lada V. |
collection | PubMed |
description | More than a quarter of HIV-infected individuals registered in Russia live in Siberia. Unlike Central Russia where HIV-1 subtype A6 is predominant, in most Siberian regions since 2012, a new HIV-1 CRF63_02A1 genetic variant has spread, with the share of this variant attaining 75–85% among newly identified HIV cases. Krasnoyarsk Krai is considered to be a high-risk territory according to morbidity rate and HIV infection incidence among the population. The current paper aims to study the molecular epidemiologic characteristics of HIV-1 spreading in Krasnoyarsk Krai. Phylogenetic and recombination analyses of pol (PR-RT, IN) and env regions of the virus were used for genotyping 159 HIV-1 isolated in Krasnoyarsk Krai. 57.2% of the isolates belonged to subtype A (A6) specific to Russia, 12.6% to CRF63_02A1, and 0.6% to CRF02_AG(СА), and in 29.6% HIV-1 URFs were detected, including URF63/А (23.9%), URFА/В (4.4%), and URF02/А (1.3%). In 6 of 7, HIV-1 URFА/В identical recombination model was detected; the origin of 38 URF63/А was proven to be the result of individual recombination events. Since 2015, a share of the population with newly diagnosed HIV who were infected with HIV-1 URF reached an exceptionally high rate of 38.6%. As distinct from adjacent Siberian regions, the HIV-1 CRF63_02A1 prevalence rate in Krasnoyarsk Krai is within 16%; however, the increased contribution of new HIV-1 into the regional epidemic development was observed due to the recombination of viruses of subtypes А, В, and CRF63_02A1. The difference between the described molecular epidemiologic picture in Krasnoyarsk Krai and in adjacent areas is likely caused by differences in predominant routes of HIV transmission and by more recent HIV-1 CRF63_02A1 transmission in the PWID group, which had a high prevalence of HIV-1 subtype A by the time of the new virus transmission, resulting in increased possibility of coinfection with various HIV-1 genetic variants. |
format | Online Article Text |
id | pubmed-7501552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-75015522020-09-21 Genetic Diversity of HIV-1 in Krasnoyarsk Krai: Area with High Levels of HIV-1 Recombination in Russia Maksimenko, Lada V. Totmenin, Aleksey V. Gashnikova, Mariya P. Astakhova, Ekaterina M. Skudarnov, Sergey E. Ostapova, Tatyana S. Yaschenko, Svetlana V. Meshkov, Ivan O. Bocharov, Evgeniy F. Maksyutov, Rinat А. Gashnikova, Natalya M. Biomed Res Int Research Article More than a quarter of HIV-infected individuals registered in Russia live in Siberia. Unlike Central Russia where HIV-1 subtype A6 is predominant, in most Siberian regions since 2012, a new HIV-1 CRF63_02A1 genetic variant has spread, with the share of this variant attaining 75–85% among newly identified HIV cases. Krasnoyarsk Krai is considered to be a high-risk territory according to morbidity rate and HIV infection incidence among the population. The current paper aims to study the molecular epidemiologic characteristics of HIV-1 spreading in Krasnoyarsk Krai. Phylogenetic and recombination analyses of pol (PR-RT, IN) and env regions of the virus were used for genotyping 159 HIV-1 isolated in Krasnoyarsk Krai. 57.2% of the isolates belonged to subtype A (A6) specific to Russia, 12.6% to CRF63_02A1, and 0.6% to CRF02_AG(СА), and in 29.6% HIV-1 URFs were detected, including URF63/А (23.9%), URFА/В (4.4%), and URF02/А (1.3%). In 6 of 7, HIV-1 URFА/В identical recombination model was detected; the origin of 38 URF63/А was proven to be the result of individual recombination events. Since 2015, a share of the population with newly diagnosed HIV who were infected with HIV-1 URF reached an exceptionally high rate of 38.6%. As distinct from adjacent Siberian regions, the HIV-1 CRF63_02A1 prevalence rate in Krasnoyarsk Krai is within 16%; however, the increased contribution of new HIV-1 into the regional epidemic development was observed due to the recombination of viruses of subtypes А, В, and CRF63_02A1. The difference between the described molecular epidemiologic picture in Krasnoyarsk Krai and in adjacent areas is likely caused by differences in predominant routes of HIV transmission and by more recent HIV-1 CRF63_02A1 transmission in the PWID group, which had a high prevalence of HIV-1 subtype A by the time of the new virus transmission, resulting in increased possibility of coinfection with various HIV-1 genetic variants. Hindawi 2020-09-10 /pmc/articles/PMC7501552/ /pubmed/32964045 http://dx.doi.org/10.1155/2020/9057541 Text en Copyright © 2020 Lada V. Maksimenko et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Maksimenko, Lada V. Totmenin, Aleksey V. Gashnikova, Mariya P. Astakhova, Ekaterina M. Skudarnov, Sergey E. Ostapova, Tatyana S. Yaschenko, Svetlana V. Meshkov, Ivan O. Bocharov, Evgeniy F. Maksyutov, Rinat А. Gashnikova, Natalya M. Genetic Diversity of HIV-1 in Krasnoyarsk Krai: Area with High Levels of HIV-1 Recombination in Russia |
title | Genetic Diversity of HIV-1 in Krasnoyarsk Krai: Area with High Levels of HIV-1 Recombination in Russia |
title_full | Genetic Diversity of HIV-1 in Krasnoyarsk Krai: Area with High Levels of HIV-1 Recombination in Russia |
title_fullStr | Genetic Diversity of HIV-1 in Krasnoyarsk Krai: Area with High Levels of HIV-1 Recombination in Russia |
title_full_unstemmed | Genetic Diversity of HIV-1 in Krasnoyarsk Krai: Area with High Levels of HIV-1 Recombination in Russia |
title_short | Genetic Diversity of HIV-1 in Krasnoyarsk Krai: Area with High Levels of HIV-1 Recombination in Russia |
title_sort | genetic diversity of hiv-1 in krasnoyarsk krai: area with high levels of hiv-1 recombination in russia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501552/ https://www.ncbi.nlm.nih.gov/pubmed/32964045 http://dx.doi.org/10.1155/2020/9057541 |
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