The properties of MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O and its basic study of loading methadone

The ligands of (E)-bis(p-3-nitrobenzoic acid) vinyl (C(16)H(10)N(2)O(8)) were synthesized in three steps, and then the MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O was synthesized by solvothermal method. This structure was characterized by X-ray single crystal diffraction, SEM and TG. The drug loading and in v...

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Detalles Bibliográficos
Autores principales: Linxin, Deng, Song, Li, Xuehua, Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501603/
https://www.ncbi.nlm.nih.gov/pubmed/32968738
http://dx.doi.org/10.1186/s13065-020-00709-y
Descripción
Sumario:The ligands of (E)-bis(p-3-nitrobenzoic acid) vinyl (C(16)H(10)N(2)O(8)) were synthesized in three steps, and then the MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O was synthesized by solvothermal method. This structure was characterized by X-ray single crystal diffraction, SEM and TG. The drug loading and in vitro release of Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O were also studied with Methadone as model drug. The results show that the highest loading amount of Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O to Methadone was 0.256 g/g, and the drug delivery system was a two-phase mode. The results of in vitro cytotoxicity test show that Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O has good biocompatibility.

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