The properties of MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O and its basic study of loading methadone

The ligands of (E)-bis(p-3-nitrobenzoic acid) vinyl (C(16)H(10)N(2)O(8)) were synthesized in three steps, and then the MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O was synthesized by solvothermal method. This structure was characterized by X-ray single crystal diffraction, SEM and TG. The drug loading and in v...

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Detalles Bibliográficos
Autores principales: Linxin, Deng, Song, Li, Xuehua, Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501603/
https://www.ncbi.nlm.nih.gov/pubmed/32968738
http://dx.doi.org/10.1186/s13065-020-00709-y
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author Linxin, Deng
Song, Li
Xuehua, Sun
author_facet Linxin, Deng
Song, Li
Xuehua, Sun
author_sort Linxin, Deng
collection PubMed
description The ligands of (E)-bis(p-3-nitrobenzoic acid) vinyl (C(16)H(10)N(2)O(8)) were synthesized in three steps, and then the MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O was synthesized by solvothermal method. This structure was characterized by X-ray single crystal diffraction, SEM and TG. The drug loading and in vitro release of Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O were also studied with Methadone as model drug. The results show that the highest loading amount of Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O to Methadone was 0.256 g/g, and the drug delivery system was a two-phase mode. The results of in vitro cytotoxicity test show that Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O has good biocompatibility.
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spelling pubmed-75016032020-09-22 The properties of MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O and its basic study of loading methadone Linxin, Deng Song, Li Xuehua, Sun BMC Chem Research Article The ligands of (E)-bis(p-3-nitrobenzoic acid) vinyl (C(16)H(10)N(2)O(8)) were synthesized in three steps, and then the MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O was synthesized by solvothermal method. This structure was characterized by X-ray single crystal diffraction, SEM and TG. The drug loading and in vitro release of Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O were also studied with Methadone as model drug. The results show that the highest loading amount of Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O to Methadone was 0.256 g/g, and the drug delivery system was a two-phase mode. The results of in vitro cytotoxicity test show that Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O has good biocompatibility. Springer International Publishing 2020-09-18 /pmc/articles/PMC7501603/ /pubmed/32968738 http://dx.doi.org/10.1186/s13065-020-00709-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Linxin, Deng
Song, Li
Xuehua, Sun
The properties of MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O and its basic study of loading methadone
title The properties of MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O and its basic study of loading methadone
title_full The properties of MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O and its basic study of loading methadone
title_fullStr The properties of MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O and its basic study of loading methadone
title_full_unstemmed The properties of MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O and its basic study of loading methadone
title_short The properties of MOF-Zn(2)(EBNB)(2)(BPY)(2)·2H(2)O and its basic study of loading methadone
title_sort properties of mof-zn(2)(ebnb)(2)(bpy)(2)·2h(2)o and its basic study of loading methadone
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501603/
https://www.ncbi.nlm.nih.gov/pubmed/32968738
http://dx.doi.org/10.1186/s13065-020-00709-y
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