Rapid and economical drug resistance profiling with Nanopore MinION for clinical specimens with low bacillary burden of Mycobacterium tuberculosis

OBJECTIVE: We designed and tested a Nanopore sequencing panel for direct tuberculosis drug resistance profiling. The panel targeted 10 resistance-associated loci. We assessed the feasibility of amplifying and sequencing these loci from 23 clinical specimens with low bacillary burden. RESULTS: At lea...

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Detalles Bibliográficos
Autores principales: Chan, Wai Sing, Au, Chun Hang, Chung, Yvonne, Leung, Henry Chi Ming, Ho, Dona N., Wong, Elaine Yue Ling, Lam, Tak Wah, Chan, Tsun Leung, Ma, Edmond Shiu Kwan, Tang, Bone Siu Fai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501614/
https://www.ncbi.nlm.nih.gov/pubmed/32948225
http://dx.doi.org/10.1186/s13104-020-05287-9

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