Anti-cancer agent 3-bromopyruvate reduces growth of MPNST and inhibits metabolic pathways in a representative in-vitro model

BACKGROUND: Anticancer compound 3-bromopyruvate (3-BrPA) suppresses cancer cell growth via targeting glycolytic and mitochondrial metabolism. The malignant peripheral nerve sheath tumor (MPNST), a very aggressive, therapy resistant, and Neurofibromatosis type 1 associated neoplasia, shows a high met...

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Detalles Bibliográficos
Autores principales: Linke, Christian, Wösle, Markus, Harder, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501688/
https://www.ncbi.nlm.nih.gov/pubmed/32948135
http://dx.doi.org/10.1186/s12885-020-07397-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501688/
https://www.ncbi.nlm.nih.gov/pubmed/32948135
http://dx.doi.org/10.1186/s12885-020-07397-w

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