Cargando…

Anti-cancer agent 3-bromopyruvate reduces growth of MPNST and inhibits metabolic pathways in a representative in-vitro model

BACKGROUND: Anticancer compound 3-bromopyruvate (3-BrPA) suppresses cancer cell growth via targeting glycolytic and mitochondrial metabolism. The malignant peripheral nerve sheath tumor (MPNST), a very aggressive, therapy resistant, and Neurofibromatosis type 1 associated neoplasia, shows a high met...

Descripción completa

Detalles Bibliográficos
Autores principales:	Linke, Christian, Wösle, Markus, Harder, Anja
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501688/ https://www.ncbi.nlm.nih.gov/pubmed/32948135 http://dx.doi.org/10.1186/s12885-020-07397-w

Ejemplares similares

Screening the yeast genome for energetic metabolism pathways involved in a phenotypic response to the anti-cancer agent 3-bromopyruvate
por: Lis, Paweł, et al.
Publicado: (2016)

MEK inhibitors enhance therapeutic response towards ATRA in NF1 associated malignant peripheral nerve sheath tumors (MPNST) in-vitro
por: Fischer-Huchzermeyer, Susan, et al.
Publicado: (2017)

Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy
por: Gan, Lei, et al.
Publicado: (2020)

In vitro and in vivo effects of 3-bromopyruvate against Echinococcus metacestodes
por: Xin, Qi, et al.
Publicado: (2019)

BCRP expression in schwannoma, plexiform neurofibroma and MPNST
por: de Vries, Maurits, et al.
Publicado: (2017)

3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis
por: XIAN, SHU-LIN, et al.
Publicado: (2015)

3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis
por: Xian, Shu-Lin, et al.
Publicado: (2016)

Testing ATRA and MEK inhibitor PD0325901 effectiveness in a nude mouse model for human MPNST xenografts
por: Fischer-Huchzermeyer, Susan, et al.
Publicado: (2018)

3-Bromopyruvate as an Alternative Option for the Treatment of Protothecosis
por: Jagielski, Tomasz, et al.
Publicado: (2018)

Factors Within the Endoneurial Microenvironment Act to Suppress Tumorigenesis of MPNST
por: Stratton, Jo Anne, et al.
Publicado: (2018)

Chromosome 8 gain is associated with high-grade transformation in MPNST
por: Dehner, Carina, et al.
Publicado: (2021)

Malignant transformation of plexiform neurofibroma to MPNST while on MEK inhibitor
por: Fasih, Samir, et al.
Publicado: (2021)

PRC2 loss drives MPNST metastasis and matrix remodeling
por: Brockman, Qierra R., et al.
Publicado: (2022)

SHH PATHWAY ACTIVATION IN DEDIFFERENTIATION DURING TUMOR PROGRESSION IN MPNST
por: Yakubov, R Y, et al.
Publicado: (2023)

Diverse Stakeholders of Tumor Metabolism: An Appraisal of the Emerging Approach of Multifaceted Metabolic Targeting by 3-Bromopyruvate
por: Yadav, Saveg, et al.
Publicado: (2019)

Hexokinase II inhibition by 3-bromopyruvate sensitizes myeloid leukemic cells K-562 to anti-leukemic drug, daunorubicin
por: Rai, Yogesh, et al.
Publicado: (2019)

Unmasking Intra-Tumoral Heterogeneity and Clonal Evolution in NF1-MPNST
por: Moon, Chang-In, et al.
Publicado: (2020)

Transport of 3-bromopyruvate across the human erythrocyte membrane
por: Sadowska-Bartosz, Izabela, et al.
Publicado: (2014)

Tumor Energy Metabolism and Potential of 3-Bromopyruvate as an Inhibitor of Aerobic Glycolysis: Implications in Tumor Treatment
por: Fan, Tengjiao, et al.
Publicado: (2019)

Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST
por: Keng, Vincent W., et al.
Publicado: (2012)

Knockdown of MSI2 inhibits metastasis by interacting with caveolin-1 and inhibiting its ubiquitylation in human NF1-MPNST cells
por: Yang, Kang, et al.
Publicado: (2020)

Construction and Evaluation of Folic Acid-Modified 3-Bromopyruvate Cubosomes
por: Hou, Fangyan, et al.
Publicado: (2020)

Mitochondrial Function Are Disturbed in the Presence of the Anticancer Drug, 3-Bromopyruvate
por: Cal, Magdalena, et al.
Publicado: (2021)

Correction: Knockdown of MSI2 inhibits metastasis by interacting with caveolin-1 and inhibiting its ubiquitylation in human NF1-MPNST cells
por: Yang, Kang, et al.
Publicado: (2020)

Inhibition of hexokinase-2 with targeted liposomal 3-bromopyruvate in an ovarian tumor spheroid model of aerobic glycolysis
por: Gandham, Srujan Kumar, et al.
Publicado: (2015)

Monozygotic twins with Neurofibromatosis type 1, concordant phenotype and synchronous development of MPNST and metastasis
por: Melean, German, et al.
Publicado: (2010)

Survivin Expression and Prognostic Significance in Pediatric Malignant Peripheral Nerve Sheath Tumors (MPNST)
por: Alaggio, Rita, et al.
Publicado: (2013)

CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin
por: Kendall, Jed J., et al.
Publicado: (2016)

Aberrant ATRX protein expression is associated with poor overall survival in NF1-MPNST
por: Lu, Hsiang-Chih, et al.
Publicado: (2018)

NFB-01. FUNCTIONAL CHARACTERIZATION OF ATRX LOSS IN NF1-ASSOCIATED GLIOMA AND MPNST
por: Yuan, Ming, et al.
Publicado: (2020)

Oncogenic RABL6A promotes NF1-associated MPNST progression in vivo
por: Kohlmeyer, Jordan L, et al.
Publicado: (2022)

Differentiate or Die: 3-Bromopyruvate and Pluripotency in Mouse Embryonic Stem Cells
por: Rodrigues, Ana Sofia, et al.
Publicado: (2015)

Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer
por: Sun, Yiming, et al.
Publicado: (2015)

Targeting Cancer Cells using 3-bromopyruvate for Selective Cancer Treatment
por: Baghdadi, Hussam H.
Publicado: (2017)

Delphinidin Increases the Sensitivity of Ovarian Cancer Cell Lines to 3-bromopyruvate
por: Pieńkowska, Natalia, et al.
Publicado: (2021)

3-Bromopyruvate Suppresses the Malignant Phenotype of Vemurafenib-Resistant Melanoma Cells
por: Vital, Patrik da Silva, et al.
Publicado: (2022)

In Vitro Activity of 3-Bromopyruvate, an Anticancer Compound, Against Antibiotic-Susceptible and Antibiotic-Resistant Helicobacter pylori Strains
por: Krzyżek, Paweł, et al.
Publicado: (2019)

3-Bromopyruvate-loaded bismuth sulfide nanospheres improve cancer treatment by synergizing radiotherapy with modulation of tumor metabolism
por: He, Yiman, et al.
Publicado: (2023)

Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine
por: Isayev, Orkhan, et al.
Publicado: (2014)

Plexiform malignant peripheral nerve sheath tumor(MPNST) in infancy and childhood--a case report.
por: Nam, E. S., et al.
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_0h0b3siue9s85vcj3cmd0cgts6