Cargando…

Evaluation of organ function in patients with severe COVID-19 infections

OBJECTIVE: The purpose of our study was to assess organ function in 102 patients with severe COVID-19 infections, using retrospective clinical analysis. MATERIAL AND METHODS: A retrospective analysis was conducted on 102 patients with severe COVID-19 infections. The patients were divided into a surv...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Yingjie, Du, Ziqiang, Zhu, Yanfang, Li, Wenfeng, Miao, Hongjun, Li, Zhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier España, S.L.U. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501795/
https://www.ncbi.nlm.nih.gov/pubmed/32984539
http://dx.doi.org/10.1016/j.medcle.2020.05.015
_version_ 1783584102329352192
author Zhu, Yingjie
Du, Ziqiang
Zhu, Yanfang
Li, Wenfeng
Miao, Hongjun
Li, Zhuo
author_facet Zhu, Yingjie
Du, Ziqiang
Zhu, Yanfang
Li, Wenfeng
Miao, Hongjun
Li, Zhuo
author_sort Zhu, Yingjie
collection PubMed
description OBJECTIVE: The purpose of our study was to assess organ function in 102 patients with severe COVID-19 infections, using retrospective clinical analysis. MATERIAL AND METHODS: A retrospective analysis was conducted on 102 patients with severe COVID-19 infections. The patients were divided into a survival group (n = 73) and a non-survival group (n = 29) according to their prognosis. The age, sex, underlying diseases, clinical laboratory data within 48 h (routine blood tests, ALT, AST, TBIL, ALB, BUN, CR, D-Dimer, PT, APTT, FIB, F VIII:C, CK-MB, CK, and LDH), and ventilation status were collected. The organ functions of these severe COVID-19 patients were assessed by comparing the differences between the two groups. RESULTS: AST, BUN, CR, CK-MB, LDH, and CK in the non-survival group were higher than those in the survival group, and the differences were statistically significant (P < 0.05). D-Dimer, PT, FIB, and F VIII:C in the non-survival group were higher than the values observed in the survival group, and the differences were statistically significant (P < 0.05). PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH predicted the area under the ROC curve (AUC) of the COVID19 endpoint events and were 0.721, 0.854, 0.867, 0.757, 0.699, 0.679, 0.715, 0.811, 0.935, and 0.802, respectively. CONCLUSION: The results showed that there were different degrees of damage to the liver, kidneys, blood coagulation, and heart function in the non-survival group. In addition, PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH had value in evaluating disease prognosis.
format Online
Article
Text
id pubmed-7501795
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier España, S.L.U.
record_format MEDLINE/PubMed
spelling pubmed-75017952020-09-21 Evaluation of organ function in patients with severe COVID-19 infections Zhu, Yingjie Du, Ziqiang Zhu, Yanfang Li, Wenfeng Miao, Hongjun Li, Zhuo Med Clin (Engl Ed) Original Article OBJECTIVE: The purpose of our study was to assess organ function in 102 patients with severe COVID-19 infections, using retrospective clinical analysis. MATERIAL AND METHODS: A retrospective analysis was conducted on 102 patients with severe COVID-19 infections. The patients were divided into a survival group (n = 73) and a non-survival group (n = 29) according to their prognosis. The age, sex, underlying diseases, clinical laboratory data within 48 h (routine blood tests, ALT, AST, TBIL, ALB, BUN, CR, D-Dimer, PT, APTT, FIB, F VIII:C, CK-MB, CK, and LDH), and ventilation status were collected. The organ functions of these severe COVID-19 patients were assessed by comparing the differences between the two groups. RESULTS: AST, BUN, CR, CK-MB, LDH, and CK in the non-survival group were higher than those in the survival group, and the differences were statistically significant (P < 0.05). D-Dimer, PT, FIB, and F VIII:C in the non-survival group were higher than the values observed in the survival group, and the differences were statistically significant (P < 0.05). PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH predicted the area under the ROC curve (AUC) of the COVID19 endpoint events and were 0.721, 0.854, 0.867, 0.757, 0.699, 0.679, 0.715, 0.811, 0.935, and 0.802, respectively. CONCLUSION: The results showed that there were different degrees of damage to the liver, kidneys, blood coagulation, and heart function in the non-survival group. In addition, PLT, AST, BUN, CR, D-Dimer, PT, FIB, F VIII:C, CK-MB, CK, and LDH had value in evaluating disease prognosis. Elsevier España, S.L.U. 2020-09-11 2020-09-19 /pmc/articles/PMC7501795/ /pubmed/32984539 http://dx.doi.org/10.1016/j.medcle.2020.05.015 Text en © 2020 Elsevier España, S.L.U. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Zhu, Yingjie
Du, Ziqiang
Zhu, Yanfang
Li, Wenfeng
Miao, Hongjun
Li, Zhuo
Evaluation of organ function in patients with severe COVID-19 infections
title Evaluation of organ function in patients with severe COVID-19 infections
title_full Evaluation of organ function in patients with severe COVID-19 infections
title_fullStr Evaluation of organ function in patients with severe COVID-19 infections
title_full_unstemmed Evaluation of organ function in patients with severe COVID-19 infections
title_short Evaluation of organ function in patients with severe COVID-19 infections
title_sort evaluation of organ function in patients with severe covid-19 infections
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501795/
https://www.ncbi.nlm.nih.gov/pubmed/32984539
http://dx.doi.org/10.1016/j.medcle.2020.05.015
work_keys_str_mv AT zhuyingjie evaluationoforganfunctioninpatientswithseverecovid19infections
AT duziqiang evaluationoforganfunctioninpatientswithseverecovid19infections
AT zhuyanfang evaluationoforganfunctioninpatientswithseverecovid19infections
AT liwenfeng evaluationoforganfunctioninpatientswithseverecovid19infections
AT miaohongjun evaluationoforganfunctioninpatientswithseverecovid19infections
AT lizhuo evaluationoforganfunctioninpatientswithseverecovid19infections