Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system

This article discusses standard and new disruptive strategies in the race to develop an anti-COVID-19 vaccine. We also included new bioinformatic data from our group mapping immunodominant epitopes and structural analysis of the spike protein. Another innovative approach reviewed here is the use of...

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Autores principales: de Queiroz, Nina Marí G.P., Marinho, Fabio V., Chagas, Marcelo A., Leite, Luciana C.C., Homan, E. Jane, de Magalhães, Mariana T.Q., Oliveira, Sergio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Institut Pasteur. Published by Elsevier Masson SAS. 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501874/
https://www.ncbi.nlm.nih.gov/pubmed/32961274
http://dx.doi.org/10.1016/j.micinf.2020.09.004
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author de Queiroz, Nina Marí G.P.
Marinho, Fabio V.
Chagas, Marcelo A.
Leite, Luciana C.C.
Homan, E. Jane
de Magalhães, Mariana T.Q.
Oliveira, Sergio C.
author_facet de Queiroz, Nina Marí G.P.
Marinho, Fabio V.
Chagas, Marcelo A.
Leite, Luciana C.C.
Homan, E. Jane
de Magalhães, Mariana T.Q.
Oliveira, Sergio C.
author_sort de Queiroz, Nina Marí G.P.
collection PubMed
description This article discusses standard and new disruptive strategies in the race to develop an anti-COVID-19 vaccine. We also included new bioinformatic data from our group mapping immunodominant epitopes and structural analysis of the spike protein. Another innovative approach reviewed here is the use of BCG vaccine as priming strategy and/or delivery system expressing SARS-CoV-2 antigens.
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spelling pubmed-75018742020-09-21 Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system de Queiroz, Nina Marí G.P. Marinho, Fabio V. Chagas, Marcelo A. Leite, Luciana C.C. Homan, E. Jane de Magalhães, Mariana T.Q. Oliveira, Sergio C. Microbes Infect Review This article discusses standard and new disruptive strategies in the race to develop an anti-COVID-19 vaccine. We also included new bioinformatic data from our group mapping immunodominant epitopes and structural analysis of the spike protein. Another innovative approach reviewed here is the use of BCG vaccine as priming strategy and/or delivery system expressing SARS-CoV-2 antigens. Institut Pasteur. Published by Elsevier Masson SAS. 2020 2020-09-19 /pmc/articles/PMC7501874/ /pubmed/32961274 http://dx.doi.org/10.1016/j.micinf.2020.09.004 Text en © 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
de Queiroz, Nina Marí G.P.
Marinho, Fabio V.
Chagas, Marcelo A.
Leite, Luciana C.C.
Homan, E. Jane
de Magalhães, Mariana T.Q.
Oliveira, Sergio C.
Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system
title Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system
title_full Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system
title_fullStr Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system
title_full_unstemmed Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system
title_short Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system
title_sort vaccines for covid-19: perspectives from nucleic acid vaccines to bcg as delivery vector system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501874/
https://www.ncbi.nlm.nih.gov/pubmed/32961274
http://dx.doi.org/10.1016/j.micinf.2020.09.004
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