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Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles

The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy (PTT) which generates heat and photodynamic therapy (PDT) which not only generates reactive oxygen species (ROS) but also induces a variety of anti-tumor immunity, is to kill tumors. In addition, due to strong eff...

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Autores principales: Hou, Yun-jing, Yang, Xin-xin, Liu, Rui-qi, Zhao, Di, Guo, Chen-xu, Zhu, An-chao, Wen, Mei-na, Liu, Zhao, Qu, Guo-fan, Meng, Hong-xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501968/
https://www.ncbi.nlm.nih.gov/pubmed/32982235
http://dx.doi.org/10.2147/IJN.S269321
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author Hou, Yun-jing
Yang, Xin-xin
Liu, Rui-qi
Zhao, Di
Guo, Chen-xu
Zhu, An-chao
Wen, Mei-na
Liu, Zhao
Qu, Guo-fan
Meng, Hong-xue
author_facet Hou, Yun-jing
Yang, Xin-xin
Liu, Rui-qi
Zhao, Di
Guo, Chen-xu
Zhu, An-chao
Wen, Mei-na
Liu, Zhao
Qu, Guo-fan
Meng, Hong-xue
author_sort Hou, Yun-jing
collection PubMed
description The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy (PTT) which generates heat and photodynamic therapy (PDT) which not only generates reactive oxygen species (ROS) but also induces a variety of anti-tumor immunity, is to kill tumors. In addition, due to strong efficacy in clinical treatment with minimal invasion and negligible side effects, it has received extensive attention and research in recent years. In this paper, the generations of nanomaterials in PTT and PDT are described separately. In clinical application, according to the different combination pathway of nanoparticles, it can be used to treat different diseases such as tumors, melanoma, rheumatoid and so on. In this paper, the mechanism of pathological treatment is described in detail in terms of inducing apoptosis of cancer cells by ROS produced by PDT, immunogenic cell death to provoke the maturation of dendritic cells, which in turn activate production of CD4+ T cells, CD8+T cells and memory T cells, as well as inhibiting heat shock protein (HSPs), STAT3 signal pathway and so on.
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spelling pubmed-75019682020-09-24 Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles Hou, Yun-jing Yang, Xin-xin Liu, Rui-qi Zhao, Di Guo, Chen-xu Zhu, An-chao Wen, Mei-na Liu, Zhao Qu, Guo-fan Meng, Hong-xue Int J Nanomedicine Review The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy (PTT) which generates heat and photodynamic therapy (PDT) which not only generates reactive oxygen species (ROS) but also induces a variety of anti-tumor immunity, is to kill tumors. In addition, due to strong efficacy in clinical treatment with minimal invasion and negligible side effects, it has received extensive attention and research in recent years. In this paper, the generations of nanomaterials in PTT and PDT are described separately. In clinical application, according to the different combination pathway of nanoparticles, it can be used to treat different diseases such as tumors, melanoma, rheumatoid and so on. In this paper, the mechanism of pathological treatment is described in detail in terms of inducing apoptosis of cancer cells by ROS produced by PDT, immunogenic cell death to provoke the maturation of dendritic cells, which in turn activate production of CD4+ T cells, CD8+T cells and memory T cells, as well as inhibiting heat shock protein (HSPs), STAT3 signal pathway and so on. Dove 2020-09-15 /pmc/articles/PMC7501968/ /pubmed/32982235 http://dx.doi.org/10.2147/IJN.S269321 Text en © 2020 Hou et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Hou, Yun-jing
Yang, Xin-xin
Liu, Rui-qi
Zhao, Di
Guo, Chen-xu
Zhu, An-chao
Wen, Mei-na
Liu, Zhao
Qu, Guo-fan
Meng, Hong-xue
Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
title Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
title_full Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
title_fullStr Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
title_full_unstemmed Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
title_short Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
title_sort pathological mechanism of photodynamic therapy and photothermal therapy based on nanoparticles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501968/
https://www.ncbi.nlm.nih.gov/pubmed/32982235
http://dx.doi.org/10.2147/IJN.S269321
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