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NanoPASS: an easy-to-use user interface for nanoparticle dosimetry with the 3DSDD model
Nanoparticles exhibit a specific diffusion and sedimentation behavior under cell culture conditions as used in nantoxicological in vitro testing. How a particular particle suspension behaves depends on the particular physicochemical characteristics of the particles and the cell culture system. Only...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502021/ https://www.ncbi.nlm.nih.gov/pubmed/32948196 http://dx.doi.org/10.1186/s12989-020-00368-w |
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author | Frenzel, Falko König-Mattern, Laura Stock, Valerie Voss, Linn Paul, Maxi B. Sieg, Holger Braeuning, Albert Voigt, Andreas Böhmert, Linda |
author_facet | Frenzel, Falko König-Mattern, Laura Stock, Valerie Voss, Linn Paul, Maxi B. Sieg, Holger Braeuning, Albert Voigt, Andreas Böhmert, Linda |
author_sort | Frenzel, Falko |
collection | PubMed |
description | Nanoparticles exhibit a specific diffusion and sedimentation behavior under cell culture conditions as used in nantoxicological in vitro testing. How a particular particle suspension behaves depends on the particular physicochemical characteristics of the particles and the cell culture system. Only a fraction of the nanoparticles applied to a cell culture will thus reach the cells within a given time frame. Therefore, dosimetric calculations are essential not only to determine the exact fraction of nanoparticles that has come into contact with the cells, but also to ensure experimental comparability and correct interpretation of results, respectively. Yet, the use of published dosimetry models is limited. Not the least because the correct application of these in silico tools usually requires bioinformatics knowledge, which often is perceived a hurdle. Moreover, not all models are freely available and accessible. In order to overcome this obstacle, we have now developed an easy-to-use interface for our recently published 3DSDD dosimetry model, called NanoPASS (NanoParticle Administration Sedimentation Simulator). The interface is freely available to all researchers. It will facilitate the use of in silico dosimetry in nanotoxicology and thus improve interpretation and comparability of in vitro results in the field. |
format | Online Article Text |
id | pubmed-7502021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-75020212020-09-22 NanoPASS: an easy-to-use user interface for nanoparticle dosimetry with the 3DSDD model Frenzel, Falko König-Mattern, Laura Stock, Valerie Voss, Linn Paul, Maxi B. Sieg, Holger Braeuning, Albert Voigt, Andreas Böhmert, Linda Part Fibre Toxicol Short Report Nanoparticles exhibit a specific diffusion and sedimentation behavior under cell culture conditions as used in nantoxicological in vitro testing. How a particular particle suspension behaves depends on the particular physicochemical characteristics of the particles and the cell culture system. Only a fraction of the nanoparticles applied to a cell culture will thus reach the cells within a given time frame. Therefore, dosimetric calculations are essential not only to determine the exact fraction of nanoparticles that has come into contact with the cells, but also to ensure experimental comparability and correct interpretation of results, respectively. Yet, the use of published dosimetry models is limited. Not the least because the correct application of these in silico tools usually requires bioinformatics knowledge, which often is perceived a hurdle. Moreover, not all models are freely available and accessible. In order to overcome this obstacle, we have now developed an easy-to-use interface for our recently published 3DSDD dosimetry model, called NanoPASS (NanoParticle Administration Sedimentation Simulator). The interface is freely available to all researchers. It will facilitate the use of in silico dosimetry in nanotoxicology and thus improve interpretation and comparability of in vitro results in the field. BioMed Central 2020-09-18 /pmc/articles/PMC7502021/ /pubmed/32948196 http://dx.doi.org/10.1186/s12989-020-00368-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Short Report Frenzel, Falko König-Mattern, Laura Stock, Valerie Voss, Linn Paul, Maxi B. Sieg, Holger Braeuning, Albert Voigt, Andreas Böhmert, Linda NanoPASS: an easy-to-use user interface for nanoparticle dosimetry with the 3DSDD model |
title | NanoPASS: an easy-to-use user interface for nanoparticle dosimetry with the 3DSDD model |
title_full | NanoPASS: an easy-to-use user interface for nanoparticle dosimetry with the 3DSDD model |
title_fullStr | NanoPASS: an easy-to-use user interface for nanoparticle dosimetry with the 3DSDD model |
title_full_unstemmed | NanoPASS: an easy-to-use user interface for nanoparticle dosimetry with the 3DSDD model |
title_short | NanoPASS: an easy-to-use user interface for nanoparticle dosimetry with the 3DSDD model |
title_sort | nanopass: an easy-to-use user interface for nanoparticle dosimetry with the 3dsdd model |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502021/ https://www.ncbi.nlm.nih.gov/pubmed/32948196 http://dx.doi.org/10.1186/s12989-020-00368-w |
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