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The Role of Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review

Endoplasmic reticulum (ER) stress, defined as prolonged disturbances in protein folding and accumulation of unfolded proteins in the ER. Perturbation of the ER, such as distribution of oxidative stress, iron imbalance, Ca(2+) leakage, protein overload, and hypoxia, can cause ER stress. The cell reac...

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Autores principales: Karna, Keshab Kumar, Shin, Yu Seob, Choi, Bo Ram, Kim, Hye Kyung, Park, Jong Kwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Sexual Medicine and Andrology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502313/
https://www.ncbi.nlm.nih.gov/pubmed/31385474
http://dx.doi.org/10.5534/wjmh.190038
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author Karna, Keshab Kumar
Shin, Yu Seob
Choi, Bo Ram
Kim, Hye Kyung
Park, Jong Kwan
author_facet Karna, Keshab Kumar
Shin, Yu Seob
Choi, Bo Ram
Kim, Hye Kyung
Park, Jong Kwan
author_sort Karna, Keshab Kumar
collection PubMed
description Endoplasmic reticulum (ER) stress, defined as prolonged disturbances in protein folding and accumulation of unfolded proteins in the ER. Perturbation of the ER, such as distribution of oxidative stress, iron imbalance, Ca(2+) leakage, protein overload, and hypoxia, can cause ER stress. The cell reacts to ER stress by activating protective pathways, called the unfolded protein response (UPR), which is comprised of cellular mechanisms aimed for maintaining cellular homeostasis or, in case of excessively severe stress, at the initiation of cellular apoptosis. The three UPR signaling pathways from the ER stress sensors are initiated by activating transcription factor 6, inositol requiring enzyme 1, and protein kinase RNA-activated-like ER kinase. A number of physiological and pathological conditions, environmental toxicants and variety of pharmacological agents showed disruption of proper ER functions and thereby cause ER stress in male reproductive organ in rat model. The present review summarizes the existing data concerning the molecular and biological mechanism of ER stress in male reproduction and male infertility. ER stress initiated cell death pathway has been related to several diseases, including hypoxia, heath disease, diabetes, and Parkinson's disease. Although there is not enough evidence to prove the relationship between ER stress and male infertility in human, most studies in this review found that ER stress was correlated with male reproduction and infertility in animal models. The ER stress could be novel signaling pathway of regulating male reproductive cellular apoptosis. Infertility might be a result of disturbing the ER stress response during the process of male reproduction.
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spelling pubmed-75023132020-10-01 The Role of Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review Karna, Keshab Kumar Shin, Yu Seob Choi, Bo Ram Kim, Hye Kyung Park, Jong Kwan World J Mens Health Review Article Endoplasmic reticulum (ER) stress, defined as prolonged disturbances in protein folding and accumulation of unfolded proteins in the ER. Perturbation of the ER, such as distribution of oxidative stress, iron imbalance, Ca(2+) leakage, protein overload, and hypoxia, can cause ER stress. The cell reacts to ER stress by activating protective pathways, called the unfolded protein response (UPR), which is comprised of cellular mechanisms aimed for maintaining cellular homeostasis or, in case of excessively severe stress, at the initiation of cellular apoptosis. The three UPR signaling pathways from the ER stress sensors are initiated by activating transcription factor 6, inositol requiring enzyme 1, and protein kinase RNA-activated-like ER kinase. A number of physiological and pathological conditions, environmental toxicants and variety of pharmacological agents showed disruption of proper ER functions and thereby cause ER stress in male reproductive organ in rat model. The present review summarizes the existing data concerning the molecular and biological mechanism of ER stress in male reproduction and male infertility. ER stress initiated cell death pathway has been related to several diseases, including hypoxia, heath disease, diabetes, and Parkinson's disease. Although there is not enough evidence to prove the relationship between ER stress and male infertility in human, most studies in this review found that ER stress was correlated with male reproduction and infertility in animal models. The ER stress could be novel signaling pathway of regulating male reproductive cellular apoptosis. Infertility might be a result of disturbing the ER stress response during the process of male reproduction. Korean Society for Sexual Medicine and Andrology 2020-10 2019-07-12 /pmc/articles/PMC7502313/ /pubmed/31385474 http://dx.doi.org/10.5534/wjmh.190038 Text en Copyright © 2020 Korean Society for Sexual Medicine and Andrology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Karna, Keshab Kumar
Shin, Yu Seob
Choi, Bo Ram
Kim, Hye Kyung
Park, Jong Kwan
The Role of Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review
title The Role of Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review
title_full The Role of Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review
title_fullStr The Role of Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review
title_full_unstemmed The Role of Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review
title_short The Role of Endoplasmic Reticulum Stress Response in Male Reproductive Physiology and Pathology: A Review
title_sort role of endoplasmic reticulum stress response in male reproductive physiology and pathology: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502313/
https://www.ncbi.nlm.nih.gov/pubmed/31385474
http://dx.doi.org/10.5534/wjmh.190038
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