A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer

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Tumor heterogeneity and cisplatin resistance are major causes of tumor relapse and poor survival. Here, we show that in lung cancer, interaction between paxillin (PXN) and integrin β4 (ITGB4), components of the focal adhesion (FA) complex, contributes to cisplatin resistance. Knocking down PXN and I...

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Detalles Bibliográficos
Autores principales: Mohanty, Atish, Nam, Arin, Pozhitkov, Alex, Yang, Lu, Srivastava, Saumya, Nathan, Anusha, Wu, Xiwei, Mambetsariev, Isa, Nelson, Michael, Subbalakshmi, A.R., Guo, Linlin, Nasser, Mohd W., Batra, Surinder K., Orban, John, Jolly, Mohit Kumar, Massarelli, Erminia, Kulkarni, Prakash, Salgia, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502350/
https://www.ncbi.nlm.nih.gov/pubmed/32947124
http://dx.doi.org/10.1016/j.isci.2020.101496
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